Abstract
Membranous nephropathy (MN), an autoimmune kidney disease and leading cause of nephrotic syndrome, leads to kidney failure in up to one-third of affected individuals. Most MN cases are due to an autoimmune reaction against the phospholipase A2 receptor (PLA2R) located on kidney podocytes. Serum PLA2R antibody quantification is now part of routine clinical practice because antibody titers correlate with disease activity and treatment response. Recent advances in target antigen detection have led to the discovery of more than 20 other podocyte antigens, yet the clinical impact of additional antigen detection remains unknown and is under active investigation. Here we review recent findings and hypothesize how current research will inform future care of patients with MN.
Original language | English (US) |
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Pages (from-to) | 219-332 |
Number of pages | 114 |
Journal | Annual review of medicine |
Volume | 75 |
DOIs | |
State | Published - Jan 29 2024 |
Keywords
- antibody-mediated kidney disease
- autoimmunity
- kidney disease
- membranous nephropathy
- nephrotic syndrome
- podocyte antigens
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology