Novel pharmacotherapy for fibromyalgia

Patrick B. Wood, Andrew J. Holman, Kim D. Jones

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Fibromyalgia is a common disorder that is characterized by chronic wide-spread pain, tenderness to light palpation, fatigue and sleep disturbances. The present lack of a well-accepted model of the disorder has hampered progress towards adequate treatment. A review of potential models to explain the pathophysiology underlying its primary symptom (i.e., chronic widespread pain) lends insight on the therapeutic potential of novel therapies. Following this, a mechanistic evaluation of those medications that are under consideration for the treatment of the disorder is offered. Adequate treatment will be likely to involve the identification of biologic sub-groups within the greater fibromyalgia construct. Key insights from basic research are the basis for increased optimism for effective relief among patients and clinicians.

Original languageEnglish (US)
Pages (from-to)829-841
Number of pages13
JournalExpert Opinion on Investigational Drugs
Issue number6
StatePublished - Jun 2007
Externally publishedYes


  • Central sensitization
  • Chronic widespread pain
  • Descending inhibition
  • Dopamine
  • Fibromyalgia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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