NTRK-fusions in pediatric thyroid tumors: Current state and future perspectives

Victoria Casado-Medrano; Alison O'Neill; Stephen Halada; Theodore W. Laetsch; Andrew J. Bauer; Aime T. Franco

doi:10.1016/j.cancergen.2022.02.009

NTRK-fusions in pediatric thyroid tumors: Current state and future perspectives

Victoria Casado-Medrano, Alison O'Neill, Stephen Halada, Theodore W. Laetsch, Andrew J. Bauer, Aime T. Franco

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Pediatric and adult papillary thyroid cancer (PTC) share many similar oncogenic drivers, but differ in the pathological features and outcomes of the disease. The most frequent genetic alterations in adult PTCs are mutually exclusive point mutations in BRAF or the RAS family. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are the most common genetic alterations observed. This review of the literature describes the current state of translational research in pediatric NTRK-driven thyroid cancer and highlights opportunities to improve our understanding and current models of pediatric PTC.

Original language	English (US)
Pages (from-to)	23-28
Number of pages	6
Journal	Cancer Genetics
Volume	264-265
DOIs	https://doi.org/10.1016/j.cancergen.2022.02.009
State	Published - Jun 2022
Externally published	Yes

Keywords

Adult thyroid cancer
Mouse models
NTRK fusion
Oncogene
Pediatric

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergen.2022.02.009

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title = "NTRK-fusions in pediatric thyroid tumors: Current state and future perspectives",

abstract = "Pediatric and adult papillary thyroid cancer (PTC) share many similar oncogenic drivers, but differ in the pathological features and outcomes of the disease. The most frequent genetic alterations in adult PTCs are mutually exclusive point mutations in BRAF or the RAS family. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are the most common genetic alterations observed. This review of the literature describes the current state of translational research in pediatric NTRK-driven thyroid cancer and highlights opportunities to improve our understanding and current models of pediatric PTC.",

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AU - Casado-Medrano, Victoria

AU - O'Neill, Alison

AU - Halada, Stephen

AU - Laetsch, Theodore W.

AU - Bauer, Andrew J.

AU - Franco, Aime T.

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AB - Pediatric and adult papillary thyroid cancer (PTC) share many similar oncogenic drivers, but differ in the pathological features and outcomes of the disease. The most frequent genetic alterations in adult PTCs are mutually exclusive point mutations in BRAF or the RAS family. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are the most common genetic alterations observed. This review of the literature describes the current state of translational research in pediatric NTRK-driven thyroid cancer and highlights opportunities to improve our understanding and current models of pediatric PTC.

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NTRK-fusions in pediatric thyroid tumors: Current state and future perspectives

Abstract

Keywords

ASJC Scopus subject areas

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