Obesity: A transgenerational problem linked to nutrition during pregnancy

Antonio E. Frias, Kevin L. Grove

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


The increased obstetric risks of maternal obesity have been well described. These include increased risks of gestational diabetes mellitus, preeclampsia, stillbirth, and cesarean delivery. The fetal/neonatal consequences of prenatal maternal obesity have received less attention. In addition to an increased risk of stillbirth, the fetal/neonatal consequences include increased adiposity and a metabolic status that increases the lifetime risk of obesity and diabetes. This review focuses on the clinical obstetric consequences of maternal obesity and highlights recent mechanistic insights on fetal programming as well as evidence suggesting that prenatal care provides a unique opportunity to ameliorate these risks and decrease the cycle of childhood obesity.

Original languageEnglish (US)
Pages (from-to)472-478
Number of pages7
JournalSeminars in Reproductive Medicine
Issue number6
StatePublished - 2012


  • high fat diet
  • obesity
  • placenta
  • pregnancy
  • programming

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Obstetrics and Gynecology
  • Physiology (medical)


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