TY - JOUR
T1 - Ocular Complications of Vincristine Therapy
AU - Albert, Daniel M.
AU - Wong, Vernon G.
AU - Henderson, Edward S.
PY - 1967/12
Y1 - 1967/12
N2 - Vincristine sulfate (Oncovin) is a commonly used drug in the treatment of acute leukemia and other malignancies. This paper lists a series of 20 patients with ptosis, other ocular muscle paresis, and fifth and seventh nerve involvement which appeared to have been induced by vincristine. Most showed signs of peripheral neuropathy, other cranial nerve palsies, nausea and vomiting, constipation, or alopecia as well. Toxic reactions usually improved following decreased dosage or discontinuation of drug therapy.
AB - Vincristine sulfate (Oncovin) is a commonly used drug in the treatment of acute leukemia and other malignancies. This paper lists a series of 20 patients with ptosis, other ocular muscle paresis, and fifth and seventh nerve involvement which appeared to have been induced by vincristine. Most showed signs of peripheral neuropathy, other cranial nerve palsies, nausea and vomiting, constipation, or alopecia as well. Toxic reactions usually improved following decreased dosage or discontinuation of drug therapy.
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U2 - 10.1001/archopht.1967.00980030711004
DO - 10.1001/archopht.1967.00980030711004
M3 - Article
C2 - 4294312
AN - SCOPUS:0014173986
SN - 0003-9950
VL - 78
SP - 709
EP - 713
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 6
ER -