Omega-3 Fatty Acids and Cardiovascular Disease Prevention

Thomas A. Barringer, William S. Harris

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Observational studies and early clinical trials indicated that long-chain n-3 fatty acids have a role in prevention of coronary heart disease, specifically fatal coronary heart disease. Results of recent trials have been inconsistent, although the study designs, patient populations, and n-3 doses have been quite different. Some studies have called into question whether there is any benefit from n-3 fatty acid therapy in patients who are receiving guideline-based treatment since their coronary event. Other recent trials suggest that certain patient subgroups, specifically those with diabetes or metabolic syndrome, may derive a significant benefit. Also, the only clinical trial to show a reduction in nonfatal coronary events used a higher n-3 fatty acid dose than used in the other studies, which raises the question of whether more is better for certain clinical outcomes. Only further research can resolve these questions.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalCurrent Nutrition Reports
Issue number2
StatePublished - Jun 2012
Externally publishedYes


  • Alpha Omega
  • Cardiovascular
  • Cardiovascular disease
  • Coronary heart disease
  • DART
  • DHA
  • EPA
  • GISSI-Prevenzione
  • Heart failure
  • Omega-3 fatty acids
  • Prevention
  • Randomized controlled trial
  • SU.FOL.OM3
  • n-3 fatty acids

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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