On Water and its Effect on the Performance of T1-Shortening Contrast Agents

Katherine M. Payne, Jennifer M. Wilds, Fabio Carniato, Mauro Botta, Mark Woods

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The performance of low molecular weight Gd3+ chelates as T1-shortening contrast agents for MRI is limited by their rapid rate of molecular tumbling, which makes them very sensitive to factors that alter the rate of molecular reorientation. Unlike the interactions of these chelates with other solutes present in solution, which have been widely studied, the effect of the solvent water itself on tumbling seems to have been largely ignored. Water has long been known to adopt structures that vary from freely diffusing molecules on one extreme and a more “ice-like” structure on the other. A variety of salts can be used to alter this “structure” of water. Relaxometric studies on inner and outersphere Gd3+ chelates were performed in the presence of both structure making and structure breaking salts. The addition of structure-making salts to low molecular weight Gd3+ chelates was found to increase both the second- and outer-sphere contributions to relaxivity. These results point to a slowing of molecular tumbling arising from an increase solvent structure and therefore microviscosity. The implication of these findings is that the performance of low molecular weight Gd3+ contrast agents is not, as generally assumed, constant in the absence of secondary interactions but may vary depending upon the nature of the solution in which it is dissolved.

Original languageEnglish (US)
Pages (from-to)880-888
Number of pages9
JournalIsrael Journal of Chemistry
Issue number9
StatePublished - Sep 2017


  • Chaotrope
  • Contrast Agents
  • Kosmotrope
  • Relaxivity
  • Water Structure

ASJC Scopus subject areas

  • General Chemistry


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