Operant conditioning of trigeminally-evoked cortical potentials: Correlated effects on facial nociception

Robert Dowman; J. Peter Rosenfeld; Mary Heinricher

doi:10.1016/0006-8993(83)90967-8

Operant conditioning of trigeminally-evoked cortical potentials: Correlated effects on facial nociception

Robert Dowman, J. Peter Rosenfeld, Mary Heinricher

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effects of operant conditioning somatosensory evoked potential (SEP) amplitude on nociceptive sensitivity were studied in albino rats. SEPs were evoked by stimulation to the descending trigeminal tract. Rewarding medial forebrain bundle stimulation (at intensities predetermined to sustain bar pressing) was made contingent upon the animal making the amplitude of the SEP 0.5 standard deviation (S.D.) larger (uptraining) or 0.5 S.D. smaller (downtraining) than the predetermined mean value. Nociceptive sensitivity was measured immediately following the conditioning session by heating the rat's face and noting the latency of a defensive face rubbing response directed at the area of the face. Increasing the amplitude of the SEP (uptraining) was associated with a decrease in noxious sensitivity. Decreasing the amplitude of the SEP (downtraining) was associated with an increase in noxious sensitivity.

Original language	English (US)
Pages (from-to)	111-118
Number of pages	8
Journal	Brain research
Volume	269
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(83)90967-8
State	Published - Jun 13 1983
Externally published	Yes

Keywords

operant conditioning of neural activity
pain
somatosensory evoked potential
trigeminal

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(83)90967-8

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title = "Operant conditioning of trigeminally-evoked cortical potentials: Correlated effects on facial nociception",

abstract = "The effects of operant conditioning somatosensory evoked potential (SEP) amplitude on nociceptive sensitivity were studied in albino rats. SEPs were evoked by stimulation to the descending trigeminal tract. Rewarding medial forebrain bundle stimulation (at intensities predetermined to sustain bar pressing) was made contingent upon the animal making the amplitude of the SEP 0.5 standard deviation (S.D.) larger (uptraining) or 0.5 S.D. smaller (downtraining) than the predetermined mean value. Nociceptive sensitivity was measured immediately following the conditioning session by heating the rat's face and noting the latency of a defensive face rubbing response directed at the area of the face. Increasing the amplitude of the SEP (uptraining) was associated with a decrease in noxious sensitivity. Decreasing the amplitude of the SEP (downtraining) was associated with an increase in noxious sensitivity.",

keywords = "operant conditioning of neural activity, pain, somatosensory evoked potential, trigeminal",

author = "Robert Dowman and {Peter Rosenfeld}, J. and Mary Heinricher",

note = "Funding Information: Supported by NIDR Grant DE05204 and NIGMS Grant GM23696 to J.P.R; NSERC (Canada) Grant 53-304-10-SO-1001 to R.D.J. D. Rosenfeld prepared graphics.",

year = "1983",

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doi = "10.1016/0006-8993(83)90967-8",

language = "English (US)",

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pages = "111--118",

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AU - Peter Rosenfeld, J.

AU - Heinricher, Mary

N1 - Funding Information: Supported by NIDR Grant DE05204 and NIGMS Grant GM23696 to J.P.R; NSERC (Canada) Grant 53-304-10-SO-1001 to R.D.J. D. Rosenfeld prepared graphics.

PY - 1983/6/13

Y1 - 1983/6/13

N2 - The effects of operant conditioning somatosensory evoked potential (SEP) amplitude on nociceptive sensitivity were studied in albino rats. SEPs were evoked by stimulation to the descending trigeminal tract. Rewarding medial forebrain bundle stimulation (at intensities predetermined to sustain bar pressing) was made contingent upon the animal making the amplitude of the SEP 0.5 standard deviation (S.D.) larger (uptraining) or 0.5 S.D. smaller (downtraining) than the predetermined mean value. Nociceptive sensitivity was measured immediately following the conditioning session by heating the rat's face and noting the latency of a defensive face rubbing response directed at the area of the face. Increasing the amplitude of the SEP (uptraining) was associated with a decrease in noxious sensitivity. Decreasing the amplitude of the SEP (downtraining) was associated with an increase in noxious sensitivity.

AB - The effects of operant conditioning somatosensory evoked potential (SEP) amplitude on nociceptive sensitivity were studied in albino rats. SEPs were evoked by stimulation to the descending trigeminal tract. Rewarding medial forebrain bundle stimulation (at intensities predetermined to sustain bar pressing) was made contingent upon the animal making the amplitude of the SEP 0.5 standard deviation (S.D.) larger (uptraining) or 0.5 S.D. smaller (downtraining) than the predetermined mean value. Nociceptive sensitivity was measured immediately following the conditioning session by heating the rat's face and noting the latency of a defensive face rubbing response directed at the area of the face. Increasing the amplitude of the SEP (uptraining) was associated with a decrease in noxious sensitivity. Decreasing the amplitude of the SEP (downtraining) was associated with an increase in noxious sensitivity.

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KW - pain

KW - somatosensory evoked potential

KW - trigeminal

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Operant conditioning of trigeminally-evoked cortical potentials: Correlated effects on facial nociception

Abstract

Keywords

ASJC Scopus subject areas

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