Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study

G. K. Aghajanian; J. H. Kogan; B. Moghaddam

doi:10.1016/0006-8993(94)90186-4

Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study

G. K. Aghajanian, J. H. Kogan, B. Moghaddam

Research output: Contribution to journal › Article › peer-review

194 Scopus citations

Abstract

Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.

Original language	English (US)
Pages (from-to)	126-130
Number of pages	5
Journal	Brain research
Volume	636
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(94)90186-4
State	Published - Feb 4 1994
Externally published	Yes

Keywords

Aspartate
Excitatory amino acid
Glutamate
Locus coeruleus
Microdialysis
Naltrexone
Opiate withdrawal

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)90186-4

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abstract = "Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.",

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T1 - Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus

T2 - an in vivo microdialysis study

AU - Aghajanian, G. K.

AU - Kogan, J. H.

AU - Moghaddam, B.

PY - 1994/2/4

Y1 - 1994/2/4

N2 - Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.

AB - Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.

KW - Aspartate

KW - Excitatory amino acid

KW - Glutamate

KW - Locus coeruleus

KW - Microdialysis

KW - Naltrexone

KW - Opiate withdrawal

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Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study

Abstract

Keywords

ASJC Scopus subject areas

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