Optical coherence tomography split-spectrum amplitude-decorrelation optoretinography

Siyu Chen; Shuibin Ni; Alfonso Jiménez-Villar; Yifan Jian; Yali Jia; David Huang

doi:10.1364/OL.492178

Optical coherence tomography split-spectrum amplitude-decorrelation optoretinography

Siyu Chen, Shuibin Ni, Alfonso Jiménez-Villar, Yifan Jian, Yali Jia, David Huang

Ophthalmology

Research output: Contribution to journal › Article › peer-review

Abstract

This pilot study reports the development of optical coherence tomography (OCT) split-spectrum amplitude-decorrelation optoretinography (SSADOR) that measures spatially resolved photoreceptor response to light stimuli. Using spectrally multiplexed narrowband OCT, SSADOR improves sensitivity to microscopic changes without the need for cellular resolution or optical phase detection. Therefore, a large field of view (up to 3 × 1 mm² demonstrated) using conventional OCT instrument design can be achieved, paving the way for clinical translation. SSADOR promises a fast, objective, and quantifiable functional biomarker for photoreceptor damage in the macula.

Original language	English (US)
Pages (from-to)	3921-3924
Number of pages	4
Journal	Optics Letters
Volume	48
Issue number	15
DOIs	https://doi.org/10.1364/OL.492178
State	Published - Aug 1 2023

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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title = "Optical coherence tomography split-spectrum amplitude-decorrelation optoretinography",

abstract = "This pilot study reports the development of optical coherence tomography (OCT) split-spectrum amplitude-decorrelation optoretinography (SSADOR) that measures spatially resolved photoreceptor response to light stimuli. Using spectrally multiplexed narrowband OCT, SSADOR improves sensitivity to microscopic changes without the need for cellular resolution or optical phase detection. Therefore, a large field of view (up to 3 × 1 mm2 demonstrated) using conventional OCT instrument design can be achieved, paving the way for clinical translation. SSADOR promises a fast, objective, and quantifiable functional biomarker for photoreceptor damage in the macula.",

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AU - Chen, Siyu

AU - Ni, Shuibin

AU - Jiménez-Villar, Alfonso

AU - Jian, Yifan

AU - Jia, Yali

AU - Huang, David

PY - 2023/8/1

Y1 - 2023/8/1

N2 - This pilot study reports the development of optical coherence tomography (OCT) split-spectrum amplitude-decorrelation optoretinography (SSADOR) that measures spatially resolved photoreceptor response to light stimuli. Using spectrally multiplexed narrowband OCT, SSADOR improves sensitivity to microscopic changes without the need for cellular resolution or optical phase detection. Therefore, a large field of view (up to 3 × 1 mm2 demonstrated) using conventional OCT instrument design can be achieved, paving the way for clinical translation. SSADOR promises a fast, objective, and quantifiable functional biomarker for photoreceptor damage in the macula.

AB - This pilot study reports the development of optical coherence tomography (OCT) split-spectrum amplitude-decorrelation optoretinography (SSADOR) that measures spatially resolved photoreceptor response to light stimuli. Using spectrally multiplexed narrowband OCT, SSADOR improves sensitivity to microscopic changes without the need for cellular resolution or optical phase detection. Therefore, a large field of view (up to 3 × 1 mm2 demonstrated) using conventional OCT instrument design can be achieved, paving the way for clinical translation. SSADOR promises a fast, objective, and quantifiable functional biomarker for photoreceptor damage in the macula.

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Optical coherence tomography split-spectrum amplitude-decorrelation optoretinography

Abstract

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