Abstract
Alteration in regional cerebral blood flow (CBF) is the direct result of changes in neuronal activity. It is crucial to monitor the spatio-temporal characteristics of cerebro-vascular blood perfusion in the studies of cerebral diseases. Optical micro-angiography (OMAG) is a recently developed imaging technique capable of resolving 3D distribution of dynamic blood perfusion at a capillary level resolution within microcirculatory beds in vivo. The authors report the applications of OMAG in mouse ischemic stroke model. The study demonstrates that OMAG is a useful method capable of providing in vivo serial assessment of 3D cerebro-vascular pathophysiology with high sensitivity, and therefore, has the potential for use in the study of brain disorders and repairs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 57-63 |
| Number of pages | 7 |
| Journal | Journal of Biophotonics |
| Volume | 4 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Jan 2011 |
Keywords
- Cerebro-vascular blood perfusion
- Ischemic stroke
- Optical micro-angiography (OMAG)
ASJC Scopus subject areas
- Chemistry(all)
- Materials Science(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Engineering(all)
- Physics and Astronomy(all)