Optimizing response of the neonate and infant to cardiopulmonary bypass.

Ross M. Ungerleider, Irving Shen

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Despite the ability to surgically correct complex defects in neonates and infants, limitations in outcome are sometimes encountered in relation to exposure to cardiopulmonary bypass (CPB). The deleterious effects of CPB in neonates are often pronounced because of their immature tissue/organ function and the disparity between the CPB circuit size and the patient. A variety of techniques that have been developed to prevent or lessen tissue edema, including miniaturization of the circuit and oxygenator, prime additives (eg, albumin, steroids), biocompatible circuitry, and variations in perfusion strategies, are discussed as are post-CPB strategies such as modified ultrafiltration, which removes inflammatory mediator-rich fluid from the patient and bypass circuit. With optimization of the response of the infant to our systems used during repair of their cardiac lesion, we will see significant improvement in surgical outcomes.

Original languageEnglish (US)
Pages (from-to)140-146
Number of pages7
JournalSeminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual
Issue number1
StatePublished - 2003

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Cardiology and Cardiovascular Medicine


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