Other Neurologic Disorders Associated with Gastrointestinal Disease

Ronald F. Pfeiffer

Research output: Chapter in Book/Report/Conference proceedingChapter


Many gastrointestinal diseases have extraintestinal manifestations including neurologic involvement. Malabsorption, which can result from diseases that damage absorptive sites in the small intestine, such as inflammatory bowel disease and tropical sprue, or may develop following bariatric surgical procedures in which absorptive sites may be bypassed or removed, can result in vitamin and other nutrient deficiencies that produce neurologic dysfunction. Disease processes involving immunologic mechanisms, in which both the gastrointestinal and nervous systems are attacked, such as celiac disease, may also produce neurologic symptoms. Neurologic dysfunction in hepatic disease most often is the result of failure of the liver to adequately perform its detoxifying function, but in the case of fulminant hepatic failure cerebral edema is the life-threatening consequence. Prompt recognition of these disorders is vitally important, since many of the neurologic manifestations of gastrointestinal disease are treatable.

Original languageEnglish (US)
Title of host publicationAminoff's Neurology and General Medicine
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Number of pages17
ISBN (Print)9780124077102
StatePublished - Apr 2014
Externally publishedYes


  • Bariatric surgery
  • Crohn disease
  • Gluten sensitivity
  • Malabsorption
  • Neurogastroenterology
  • Wilson disease

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)


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