Ototoxicity monitoring in children treated with platinum chemotherapy

Beth Brooks, Kristin Knight

Research output: Contribution to journalComment/debatepeer-review

39 Scopus citations


Objective: To review the prevalence, mechanisms, clinical presentation, risk factors and implications of platinum-induced ototoxicity in paediatric cancer patients based on published evidence, discuss options for monitoring hearing in young children during treatment and review long-term follow-up guidelines. Design: Narrative literature review. Results: Children treated with cisplatin are at high risk of hearing loss and early, accurate identification of ototoxicity is important for medical decision making and hearing rehabilitation. Challenges of monitoring hearing in young children during cancer treatment and options for monitoring hearing are discussed. Conclusion: Hearing loss has important consequences for the survivors of childhood cancer including communication, learning, cognition and quality of life. Due to the presentation and configuration of ototoxic hearing loss, the test frequencies that are prioritised and the sequence of testing may differ from standard paediatric hearing evaluations. Hearing should be monitored during treatment and after completion of therapy.

Original languageEnglish (US)
Pages (from-to)S34-S40
JournalInternational journal of audiology
Issue numbersup4
StatePublished - Aug 24 2018
Externally publishedYes


  • Hearing loss
  • carboplatin
  • children
  • cisplatin
  • ototoxicity

ASJC Scopus subject areas

  • Language and Linguistics
  • Linguistics and Language
  • Speech and Hearing


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