Oxiperomide in tardive dyskinesia

D. E. Casey, J. Gerlach

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Tardive dyskinesia can be suppressed by dopaminergic receptor blockers, but often at the cost of reciprocal increase in Parkinsonism. Oxiperomide, a dopaminergic antagonist that has been shown to reduce levodopa-induced dyskinesias without producing an equal aggravation of Parkinsonism, was evaluated in a blind placebo-controlled trial in 10 patients with tardive dyskinesia. It decreased tardive dyskinesia significantly (p<0.01) without significantly provoking or increasing Parkinsonism. There was no relationship between either tardive dyskinesia or existence of more than one population of dopamine receptors involved in controlling extrapyramidal function. Although oxiperomide is only a palliative suppressing agent in tardive dyskinesia, as the symptoms returned when the drug was stopped, it is an interesting agent in the search for selective dopaminergic receptor blockers.

Original languageEnglish (US)
Pages (from-to)264-267
Number of pages4
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number3
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health


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