Oxygen Delivery and Consumption: A Macrocirculatory Perspective

Dane Nichols, Nathan D. Nielsen

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Severe sepsis is a leading cause of death and resource use throughout the world. This article examines the relationship of oxygen delivery to oxygen use under varying conditions. Topics reviewed include the concept of the critical dissolved oxygen, concerns over shared measurement errors in obtaining estimates of oxygen consumption, seminal articles in this area, and the practice of early goal directed therapy.

Original languageEnglish (US)
Pages (from-to)239-253
Number of pages15
JournalCritical Care Clinics
Issue number2
StatePublished - Apr 2010


  • Early goal-directed therapy
  • Oxygen consumption
  • Oxygen delivery

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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