Oxygen reactions of the copper oxidases

James W. Whittaker

doi:10.1042/bse0340155

Oxygen reactions of the copper oxidases

James W. Whittaker

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The copper oxidases are a remarkable family of metalloenzymes that have evolved specialized mechanisms to accomplish the controlled reduction of dioxygen, delivering the equivalent of H₂ from organic substrates to O₂ to form hydrogen peroxide, a ubiquitous oxygen metabolite that is involved in a wide range of biological interactions. These enzymes display their virtuosity in dioxygen chemistry by harnessing the oxidizing power of that molecule not only during catalytic turnover, but also in transforming themselves in the biogenesis of their catalytic redox cofactor.

Original language	English (US)
Pages (from-to)	155-172
Number of pages	18
Journal	Essays in Biochemistry
Volume	34
DOIs	https://doi.org/10.1042/bse0340155
State	Published - 1999

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Access to Document

10.1042/bse0340155

Cite this

@article{4b69f6946bc74026a90852d72e6d5a5c,

title = "Oxygen reactions of the copper oxidases",

abstract = "The copper oxidases are a remarkable family of metalloenzymes that have evolved specialized mechanisms to accomplish the controlled reduction of dioxygen, delivering the equivalent of H2 from organic substrates to O2 to form hydrogen peroxide, a ubiquitous oxygen metabolite that is involved in a wide range of biological interactions. These enzymes display their virtuosity in dioxygen chemistry by harnessing the oxidizing power of that molecule not only during catalytic turnover, but also in transforming themselves in the biogenesis of their catalytic redox cofactor.",

author = "Whittaker, {James W.}",

year = "1999",

doi = "10.1042/bse0340155",

language = "English (US)",

volume = "34",

pages = "155--172",

journal = "Essays in Biochemistry",

issn = "0071-1365",

publisher = "Portland Press Ltd.",

}

TY - JOUR

T1 - Oxygen reactions of the copper oxidases

AU - Whittaker, James W.

PY - 1999

Y1 - 1999

N2 - The copper oxidases are a remarkable family of metalloenzymes that have evolved specialized mechanisms to accomplish the controlled reduction of dioxygen, delivering the equivalent of H2 from organic substrates to O2 to form hydrogen peroxide, a ubiquitous oxygen metabolite that is involved in a wide range of biological interactions. These enzymes display their virtuosity in dioxygen chemistry by harnessing the oxidizing power of that molecule not only during catalytic turnover, but also in transforming themselves in the biogenesis of their catalytic redox cofactor.

AB - The copper oxidases are a remarkable family of metalloenzymes that have evolved specialized mechanisms to accomplish the controlled reduction of dioxygen, delivering the equivalent of H2 from organic substrates to O2 to form hydrogen peroxide, a ubiquitous oxygen metabolite that is involved in a wide range of biological interactions. These enzymes display their virtuosity in dioxygen chemistry by harnessing the oxidizing power of that molecule not only during catalytic turnover, but also in transforming themselves in the biogenesis of their catalytic redox cofactor.

UR - http://www.scopus.com/inward/record.url?scp=0033289201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033289201&partnerID=8YFLogxK

U2 - 10.1042/bse0340155

DO - 10.1042/bse0340155

M3 - Article

C2 - 10730194

AN - SCOPUS:0033289201

SN - 0071-1365

VL - 34

SP - 155

EP - 172

JO - Essays in Biochemistry

JF - Essays in Biochemistry

ER -

Oxygen reactions of the copper oxidases

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this