Oxygen transport in the myocardium

J. B. Bassingthwaighte; A. Deussen; D. Beyer; I. S. Chan; G. R. Raymond; R. B. King; T. R. Bukowski; J. D. Ploger; K. Kroll; J. Revenaugh; A. Deussen; J. M. Link; K. A. Krohn

Oxygen transport in the myocardium

J. B. Bassingthwaighte, A. Deussen, D. Beyer, I. S. Chan, G. R. Raymond, R. B. King, T. R. Bukowski, J. D. Ploger, K. Kroll, J. Revenaugh, A. Deussen, J. M. Link, K. A. Krohn

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

¹⁵O-oxygen is metabolized carbon dioxide and converts to ¹⁵O-water in myocardial mitochondria. To determine the rate of this reaction from the analysis of time activity curves obtained via positron emission tomography or from outflow dilution curves, we apply a mathematical model accounting for convective and transmembrane transport, for transformation in tissue and for measures of the anatomic structures. The model describes gradients in concentrations along capillary tissue units, permeation of endothelial and parenchymal cell barriers (using appropriate binding spaces to account for O₂ binding to hemoglobin and myoglobin), production of ¹⁵O-water in parenchymal cells, and the permeation and transport of ¹⁵O-water into effluent blood. The modeling analysis gives estimates of rates of oxygen consumption which are within a few percent of estimates obtained by the standard Fick technique which uses the product of flow times the arteriovenous differences in oxygen concentrations.

Original language	English (US)
Title of host publication	Advaces in Biological Heat and Mass Transfer - 1992
Publisher	Publ by ASME
Pages	113-119
Number of pages	7
ISBN (Print)	0791811115
State	Published - 1992
Externally published	Yes
Event	Winter Annual Meeting of the American Society of Mechanical Engineers - Anaheim, CA, USA Duration: Nov 8 1992 → Nov 13 1992

Publication series

Name	American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD
Volume	231
ISSN (Print)	0272-5673

Other

Other	Winter Annual Meeting of the American Society of Mechanical Engineers
City	Anaheim, CA, USA
Period	11/8/92 → 11/13/92

ASJC Scopus subject areas

Mechanical Engineering
Fluid Flow and Transfer Processes

Cite this

Bassingthwaighte, J. B., Deussen, A., Beyer, D., Chan, I. S., Raymond, G. R., King, R. B., Bukowski, T. R., Ploger, J. D., Kroll, K., Revenaugh, J., Deussen, A., Link, J. M., & Krohn, K. A. (1992). Oxygen transport in the myocardium. In Advaces in Biological Heat and Mass Transfer - 1992 (pp. 113-119). (American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD; Vol. 231). Publ by ASME.

Bassingthwaighte, JB, Deussen, A, Beyer, D, Chan, IS, Raymond, GR, King, RB, Bukowski, TR, Ploger, JD, Kroll, K, Revenaugh, J, Deussen, A, Link, JM & Krohn, KA 1992, Oxygen transport in the myocardium. in Advaces in Biological Heat and Mass Transfer - 1992. American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD, vol. 231, Publ by ASME, pp. 113-119, Winter Annual Meeting of the American Society of Mechanical Engineers, Anaheim, CA, USA, 11/8/92.

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title = "Oxygen transport in the myocardium",

abstract = "15O-oxygen is metabolized carbon dioxide and converts to 15O-water in myocardial mitochondria. To determine the rate of this reaction from the analysis of time activity curves obtained via positron emission tomography or from outflow dilution curves, we apply a mathematical model accounting for convective and transmembrane transport, for transformation in tissue and for measures of the anatomic structures. The model describes gradients in concentrations along capillary tissue units, permeation of endothelial and parenchymal cell barriers (using appropriate binding spaces to account for O2 binding to hemoglobin and myoglobin), production of 15O-water in parenchymal cells, and the permeation and transport of 15O-water into effluent blood. The modeling analysis gives estimates of rates of oxygen consumption which are within a few percent of estimates obtained by the standard Fick technique which uses the product of flow times the arteriovenous differences in oxygen concentrations.",

author = "Bassingthwaighte, {J. B.} and A. Deussen and D. Beyer and Chan, {I. S.} and Raymond, {G. R.} and King, {R. B.} and Bukowski, {T. R.} and Ploger, {J. D.} and K. Kroll and J. Revenaugh and A. Deussen and Link, {J. M.} and Krohn, {K. A.}",

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T1 - Oxygen transport in the myocardium

AU - Bassingthwaighte, J. B.

AU - Deussen, A.

AU - Beyer, D.

AU - Chan, I. S.

AU - Raymond, G. R.

AU - King, R. B.

AU - Bukowski, T. R.

AU - Ploger, J. D.

AU - Kroll, K.

AU - Revenaugh, J.

AU - Deussen, A.

AU - Link, J. M.

AU - Krohn, K. A.

PY - 1992

Y1 - 1992

N2 - 15O-oxygen is metabolized carbon dioxide and converts to 15O-water in myocardial mitochondria. To determine the rate of this reaction from the analysis of time activity curves obtained via positron emission tomography or from outflow dilution curves, we apply a mathematical model accounting for convective and transmembrane transport, for transformation in tissue and for measures of the anatomic structures. The model describes gradients in concentrations along capillary tissue units, permeation of endothelial and parenchymal cell barriers (using appropriate binding spaces to account for O2 binding to hemoglobin and myoglobin), production of 15O-water in parenchymal cells, and the permeation and transport of 15O-water into effluent blood. The modeling analysis gives estimates of rates of oxygen consumption which are within a few percent of estimates obtained by the standard Fick technique which uses the product of flow times the arteriovenous differences in oxygen concentrations.

AB - 15O-oxygen is metabolized carbon dioxide and converts to 15O-water in myocardial mitochondria. To determine the rate of this reaction from the analysis of time activity curves obtained via positron emission tomography or from outflow dilution curves, we apply a mathematical model accounting for convective and transmembrane transport, for transformation in tissue and for measures of the anatomic structures. The model describes gradients in concentrations along capillary tissue units, permeation of endothelial and parenchymal cell barriers (using appropriate binding spaces to account for O2 binding to hemoglobin and myoglobin), production of 15O-water in parenchymal cells, and the permeation and transport of 15O-water into effluent blood. The modeling analysis gives estimates of rates of oxygen consumption which are within a few percent of estimates obtained by the standard Fick technique which uses the product of flow times the arteriovenous differences in oxygen concentrations.

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M3 - Conference contribution

AN - SCOPUS:0026993934

SN - 0791811115

T3 - American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD

SP - 113

EP - 119

BT - Advaces in Biological Heat and Mass Transfer - 1992

PB - Publ by ASME

T2 - Winter Annual Meeting of the American Society of Mechanical Engineers

Y2 - 8 November 1992 through 13 November 1992

ER -

Oxygen transport in the myocardium

Abstract

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ASJC Scopus subject areas

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