@article{f58d0f6247f34b67a9bf2acf4063e2f2,
title = "p85α neomorphic mutants: splitting away from the canonical path",
abstract = "PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.",
keywords = "MAPK, PI3K, PIK3R1, mutation, neomorph, p85a",
author = "Cheung, {Lydia W.T.} and Mills, {Gordon B.}",
note = "Funding Information: Supported by NCI 2P50 CA098258– 06, NCI U01 CA168394, Stand Up to Cancer/AACR Dream Team Transla tional Cancer Research Grant SU2C- AACR-DT0209, TCGA GDAC Grant (NIH/NCI U24 CA143883) to GBM; MDACC Uterine SPORE Career Devel opment Award (NCI P50CA098258) to LWT. Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Lydia WT Cheung and Gordon B Mills.",
year = "2015",
month = oct,
day = "2",
doi = "10.4161/23723556.2014.983388",
language = "English (US)",
volume = "2",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "4",
}