p85α neomorphic mutants: splitting away from the canonical path

Lydia W.T. Cheung, Gordon B. Mills

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


PIK3R1 (encoding the p85α subunit of phosphatidylinositol 3-kinase) is the 11th most frequently mutated gene across tumors. We recently reported neomorphic p85α mutants that induce signaling cascades not predicted by the canonical functions of p85α, suggesting the need to functionally annotate specific mutations in cancer genes for effective genome-informed personalized therapy.

Original languageEnglish (US)
Article numbere983388
JournalMolecular and Cellular Oncology
Issue number4
StatePublished - Oct 2 2015
Externally publishedYes


  • MAPK
  • PI3K
  • PIK3R1
  • mutation
  • neomorph
  • p85a

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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