Pain experienced using two different methods of endometrial biopsy: A randomized controlled trial

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31 Scopus citations


OBJECTIVE: To compare patient-reported pain, provider-reported ease of use, and tissue sampling adequacy between endometrial biopsy instruments. METHODS: Women presenting for endometrial biopsy were randomized to either Pipelle or Explora curette. The primary outcome was patient-reported pain with biopsy as measured by a 100-mm visual analog scale. Secondary outcomes included the adequacy of biopsy sample and provider-reported ease of instrument use. RESULTS: Groups were similar in respect to age, parity, ethnicity, level of dysmenorrhea, menopausal status, and biopsy indication. The most common indication for biopsy was abnormal uterine bleeding. Subject reported pain with biopsy was similar between groups (Pipelle, 6.21±2.41 cm; Explora, 6.91±2.88 cm; P=.14), as was provider-reported ease of use. Although procedure length was significantly shorter for patients in the Pipelle group (4.05±1.48 minutes compared with 5.27±2.53 minutes; P=.007), 38% of Pipelle procedures required two or more passes to obtain a sample compared with only 9% using the Explora (P=.004). The Explora group had a higher proportion of adequate samples (97% compared with 91%; P=.33). CONCLUSION: Women's pain during endometrial biopsy does not differ by type of biopsy instrument used. CLINICAL TRIAL REGISTRATION:, NCT00613925.

Original languageEnglish (US)
Pages (from-to)636-641
Number of pages6
JournalObstetrics and gynecology
Issue number3
StatePublished - Mar 2011

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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