Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease

Kenneth A. Follett; Frances M. Weaver; Matthew Stern; Kwan Hur; Crystal L. Harris; Ping Luo; William J. Marks; Johannes Rothlind; Oren Sagher; Claudia Moy; Rajesh Pahwa; Kim Burchiel; Penelope Hogarth; Eugene C. Lai; John E. Duda; Kathryn Holloway; Ali Samii; Stacy Horn; Jeff M. Bronstein; Gatana Stoner; Philip A. Starr; Richard Simpson; Gordon Baltuch; Antonio De Salles; Grant D. Huang; Domenic J. Reda

doi:10.1056/NEJMoa0907083

Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease

Kenneth A. Follett, Frances M. Weaver, Matthew Stern, Kwan Hur, Crystal L. Harris, Ping Luo, William J. Marks, Johannes Rothlind, Oren Sagher, Claudia Moy, Rajesh Pahwa, Kim Burchiel, Penelope Hogarth, Eugene C. Lai, John E. Duda, Kathryn Holloway, Ali Samii, Stacy Horn, Jeff M. Bronstein, Gatana StonerPhilip A. Starr, Richard Simpson, Gordon Baltuch, Antonio De Salles, Grant D. Huang, Domenic J. Reda

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

1071 Scopus citations

Abstract

Background: Deep-brain stimulation is the surgical procedure of choice for patients with advanced Parkinson's disease. The globus pallidus interna and the subthalamic nucleus are accepted targets for this procedure. We compared 24-month outcomes for patients who had undergone bilateral stimulation of the globus pallidus interna (pallidal stimulation) or subthalamic nucleus (subthalamic stimulation). Methods: At seven Veterans Affairs and six university hospitals, we randomly assigned 299 patients with idiopathic Parkinson's disease to undergo either pallidal stimulation (152 patients) or subthalamic stimulation (147 patients). The primary outcome was the change in motor function, as blindly assessed on the Unified Parkinson's Disease Rating Scale, part III (UPDRS-III), while patients were receiving stimulation but not receiving antiparkinsonian medication. Secondary outcomes included selfreported function, quality of life, neurocognitive function, and adverse events. Results: Mean changes in the primary outcome did not differ significantly between the two study groups (P = 0.50). There was also no significant difference in self-reported function. Patients undergoing subthalamic stimulation required a lower dose of dopaminergic agents than did those undergoing pallidal stimulation (P = 0.02). One component of processing speed (visuomotor) declined more after subthalamic stimulation than after pallidal stimulation (P = 0.03). The level of depression worsened after subthalamic stimulation and improved after pallidal stimulation (P = 0.02). Serious adverse events occurred in 51% of patients undergoing pallidal stimulation and in 56% of those undergoing subthalamic stimulation, with no significant between-group differences at 24 months. Conclusions: Patients with Parkinson's disease had similar improvement in motor function after either pallidal or subthalamic stimulation. Nonmotor factors may reasonably be included in the selection of surgical target for deep-brain stimulation.

Original language	English (US)
Pages (from-to)	2077-2091
Number of pages	15
Journal	New England Journal of Medicine
Volume	362
Issue number	22
DOIs	https://doi.org/10.1056/NEJMoa0907083
State	Published - Jun 3 2010

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General Medicine

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Follett, K. A., Weaver, F. M., Stern, M., Hur, K., Harris, C. L., Luo, P., Marks, W. J., Rothlind, J., Sagher, O., Moy, C., Pahwa, R., Burchiel, K., Hogarth, P., Lai, E. C., Duda, J. E., Holloway, K., Samii, A., Horn, S., Bronstein, J. M., ... Reda, D. J. (2010). Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. New England Journal of Medicine, 362(22), 2077-2091. https://doi.org/10.1056/NEJMoa0907083

Follett, KA, Weaver, FM, Stern, M, Hur, K, Harris, CL, Luo, P, Marks, WJ, Rothlind, J, Sagher, O, Moy, C, Pahwa, R, Burchiel, K , Hogarth, P, Lai, EC, Duda, JE, Holloway, K, Samii, A, Horn, S, Bronstein, JM, Stoner, G, Starr, PA, Simpson, R, Baltuch, G, De Salles, A, Huang, GD & Reda, DJ 2010, 'Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease', New England Journal of Medicine, vol. 362, no. 22, pp. 2077-2091. https://doi.org/10.1056/NEJMoa0907083

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title = "Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease",

abstract = "Background: Deep-brain stimulation is the surgical procedure of choice for patients with advanced Parkinson's disease. The globus pallidus interna and the subthalamic nucleus are accepted targets for this procedure. We compared 24-month outcomes for patients who had undergone bilateral stimulation of the globus pallidus interna (pallidal stimulation) or subthalamic nucleus (subthalamic stimulation). Methods: At seven Veterans Affairs and six university hospitals, we randomly assigned 299 patients with idiopathic Parkinson's disease to undergo either pallidal stimulation (152 patients) or subthalamic stimulation (147 patients). The primary outcome was the change in motor function, as blindly assessed on the Unified Parkinson's Disease Rating Scale, part III (UPDRS-III), while patients were receiving stimulation but not receiving antiparkinsonian medication. Secondary outcomes included selfreported function, quality of life, neurocognitive function, and adverse events. Results: Mean changes in the primary outcome did not differ significantly between the two study groups (P = 0.50). There was also no significant difference in self-reported function. Patients undergoing subthalamic stimulation required a lower dose of dopaminergic agents than did those undergoing pallidal stimulation (P = 0.02). One component of processing speed (visuomotor) declined more after subthalamic stimulation than after pallidal stimulation (P = 0.03). The level of depression worsened after subthalamic stimulation and improved after pallidal stimulation (P = 0.02). Serious adverse events occurred in 51% of patients undergoing pallidal stimulation and in 56% of those undergoing subthalamic stimulation, with no significant between-group differences at 24 months. Conclusions: Patients with Parkinson's disease had similar improvement in motor function after either pallidal or subthalamic stimulation. Nonmotor factors may reasonably be included in the selection of surgical target for deep-brain stimulation.",

author = "Follett, {Kenneth A.} and Weaver, {Frances M.} and Matthew Stern and Kwan Hur and Harris, {Crystal L.} and Ping Luo and Marks, {William J.} and Johannes Rothlind and Oren Sagher and Claudia Moy and Rajesh Pahwa and Kim Burchiel and Penelope Hogarth and Lai, {Eugene C.} and Duda, {John E.} and Kathryn Holloway and Ali Samii and Stacy Horn and Bronstein, {Jeff M.} and Gatana Stoner and Starr, {Philip A.} and Richard Simpson and Gordon Baltuch and {De Salles}, Antonio and Huang, {Grant D.} and Reda, {Domenic J.}",

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doi = "10.1056/NEJMoa0907083",

language = "English (US)",

volume = "362",

pages = "2077--2091",

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TY - JOUR

T1 - Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease

AU - Follett, Kenneth A.

AU - Weaver, Frances M.

AU - Stern, Matthew

AU - Hur, Kwan

AU - Harris, Crystal L.

AU - Luo, Ping

AU - Marks, William J.

AU - Rothlind, Johannes

AU - Sagher, Oren

AU - Moy, Claudia

AU - Pahwa, Rajesh

AU - Burchiel, Kim

AU - Hogarth, Penelope

AU - Lai, Eugene C.

AU - Duda, John E.

AU - Holloway, Kathryn

AU - Samii, Ali

AU - Horn, Stacy

AU - Bronstein, Jeff M.

AU - Stoner, Gatana

AU - Starr, Philip A.

AU - Simpson, Richard

AU - Baltuch, Gordon

AU - De Salles, Antonio

AU - Huang, Grant D.

AU - Reda, Domenic J.

PY - 2010/6/3

Y1 - 2010/6/3

N2 - Background: Deep-brain stimulation is the surgical procedure of choice for patients with advanced Parkinson's disease. The globus pallidus interna and the subthalamic nucleus are accepted targets for this procedure. We compared 24-month outcomes for patients who had undergone bilateral stimulation of the globus pallidus interna (pallidal stimulation) or subthalamic nucleus (subthalamic stimulation). Methods: At seven Veterans Affairs and six university hospitals, we randomly assigned 299 patients with idiopathic Parkinson's disease to undergo either pallidal stimulation (152 patients) or subthalamic stimulation (147 patients). The primary outcome was the change in motor function, as blindly assessed on the Unified Parkinson's Disease Rating Scale, part III (UPDRS-III), while patients were receiving stimulation but not receiving antiparkinsonian medication. Secondary outcomes included selfreported function, quality of life, neurocognitive function, and adverse events. Results: Mean changes in the primary outcome did not differ significantly between the two study groups (P = 0.50). There was also no significant difference in self-reported function. Patients undergoing subthalamic stimulation required a lower dose of dopaminergic agents than did those undergoing pallidal stimulation (P = 0.02). One component of processing speed (visuomotor) declined more after subthalamic stimulation than after pallidal stimulation (P = 0.03). The level of depression worsened after subthalamic stimulation and improved after pallidal stimulation (P = 0.02). Serious adverse events occurred in 51% of patients undergoing pallidal stimulation and in 56% of those undergoing subthalamic stimulation, with no significant between-group differences at 24 months. Conclusions: Patients with Parkinson's disease had similar improvement in motor function after either pallidal or subthalamic stimulation. Nonmotor factors may reasonably be included in the selection of surgical target for deep-brain stimulation.

AB - Background: Deep-brain stimulation is the surgical procedure of choice for patients with advanced Parkinson's disease. The globus pallidus interna and the subthalamic nucleus are accepted targets for this procedure. We compared 24-month outcomes for patients who had undergone bilateral stimulation of the globus pallidus interna (pallidal stimulation) or subthalamic nucleus (subthalamic stimulation). Methods: At seven Veterans Affairs and six university hospitals, we randomly assigned 299 patients with idiopathic Parkinson's disease to undergo either pallidal stimulation (152 patients) or subthalamic stimulation (147 patients). The primary outcome was the change in motor function, as blindly assessed on the Unified Parkinson's Disease Rating Scale, part III (UPDRS-III), while patients were receiving stimulation but not receiving antiparkinsonian medication. Secondary outcomes included selfreported function, quality of life, neurocognitive function, and adverse events. Results: Mean changes in the primary outcome did not differ significantly between the two study groups (P = 0.50). There was also no significant difference in self-reported function. Patients undergoing subthalamic stimulation required a lower dose of dopaminergic agents than did those undergoing pallidal stimulation (P = 0.02). One component of processing speed (visuomotor) declined more after subthalamic stimulation than after pallidal stimulation (P = 0.03). The level of depression worsened after subthalamic stimulation and improved after pallidal stimulation (P = 0.02). Serious adverse events occurred in 51% of patients undergoing pallidal stimulation and in 56% of those undergoing subthalamic stimulation, with no significant between-group differences at 24 months. Conclusions: Patients with Parkinson's disease had similar improvement in motor function after either pallidal or subthalamic stimulation. Nonmotor factors may reasonably be included in the selection of surgical target for deep-brain stimulation.

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JO - New England Journal of Medicine

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Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease

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