Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Mark Woods; Donald E. Woessner; A. Dean Sherry

doi:10.1039/b509907m

Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Mark Woods, Donald E. Woessner, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

344 Scopus citations

Abstract

This tutorial review examines the fundamental aspects of a new class of contrast media for MRI based upon the chemical shift saturation transfer (CEST) mechanism. Several paramagnetic versions called PARACEST agents have shown utility as responsive agents for reporting physiological or metabolic information by MRI. It is shown that basic NMR exchange theory can be used to predict how parameters such as chemical shift, bound water lifetimes, and relaxation rates can be optimized to maximize the sensitivity of PARACEST agents.

Original language	English (US)
Pages (from-to)	500-511
Number of pages	12
Journal	Chemical Society Reviews
Volume	35
Issue number	6
DOIs	https://doi.org/10.1039/b509907m
State	Published - May 26 2006
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1039/b509907m

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Paramagnetic lanthanide complexes as PARACEST agents for medical imaging

Abstract

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