Paraneoplastic vitelliform retinopathy associated with cutaneous or uveal melanoma and metastases

M. Sotodeh, D. Paridaens, J. Keunen, M. Van Schooneveld, G. Adamus, Seerp Baarsma

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Purpose: To report unusual vitelliform fundus findings in three cases of paraneoplastic retinopathy associated with metastasised cutaneous or uveal melanoma and in one case, a unique immunoreactivity response. Patients and Methods: Observational case series. The histories of three patients with MAR-like paraneoplastic retinopathy were reviewed. Electroretinography, Goldmann perimetry, fluorescein angiography, and in one case optical coherence tomography, immunohistochemistry and Western blotting were performed. Results: All patients revealed similar paraneoplastic vitelliform retinal abnormalities. Symptoms in two cases differed from the classical MAR syndrome. In one case, western blotting and immunohistochemistry demonstrated antibodies against 120-kDa, a soluble photoreceptor protein. No immunoreactivity to retinal bipolar cells was detected. Conclusion: The clinical, electrophysiological, and immunological findings in our patients suggest a melanoma associated para-neoplastic origin, like in MAR syndrome. However contrary to MAR syndrome, this paraneoplastic vitelliform retinopathy exhibits a peculiar fundus picture, consisting of serous macular detachment and nummular vitelliform lesions in the posterior pole. This could be an unusual presentation of MAR or a separate paraneoplastic entity.

Original languageEnglish (US)
Pages (from-to)910-914
Number of pages5
JournalKlinische Monatsblatter fur Augenheilkunde
Issue number11
StatePublished - Nov 2005


  • Melanoma
  • Metastasis
  • Paraneoplastic
  • Uveal
  • Vitelliform

ASJC Scopus subject areas

  • Ophthalmology


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