TY - JOUR
T1 - Parkinson's Disease
T2 - Follow‐up After “Drug Holiday”
AU - Feldman, Robert G.
AU - Kaye, Jeffrey A.
AU - Lannon, Margaret C.
PY - 1986
Y1 - 1986
N2 - Long‐term management of patients with Parkinson's disease includes close monitoring and frequent dose adjustment. In a small selected group of patients, complete withdrawal of l‐dopa (drug holiday) and slow reintroduction of lower doses of this drug assured continued benefit for six to 24 months. We studied 45 drug holidays in 45 patients with idiopathic Parkinson's disease. Average preholiday l‐dopa dose was 2,970 mg/d; at 24 months, it was 263 mg/d. The drug holiday resulted in reduced adverse drug effects (dyskinesias, “on‐off” phenomenon, hallucinations, and confusion), and improved functional ratings at one, six, 12, and 24 months after the drug holiday. 1986 American College of Clinical Pharmacology
AB - Long‐term management of patients with Parkinson's disease includes close monitoring and frequent dose adjustment. In a small selected group of patients, complete withdrawal of l‐dopa (drug holiday) and slow reintroduction of lower doses of this drug assured continued benefit for six to 24 months. We studied 45 drug holidays in 45 patients with idiopathic Parkinson's disease. Average preholiday l‐dopa dose was 2,970 mg/d; at 24 months, it was 263 mg/d. The drug holiday resulted in reduced adverse drug effects (dyskinesias, “on‐off” phenomenon, hallucinations, and confusion), and improved functional ratings at one, six, 12, and 24 months after the drug holiday. 1986 American College of Clinical Pharmacology
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U2 - 10.1002/j.1552-4604.1986.tb02969.x
DO - 10.1002/j.1552-4604.1986.tb02969.x
M3 - Article
C2 - 3793959
AN - SCOPUS:0023028759
SN - 0091-2700
VL - 26
SP - 662
EP - 667
JO - The Journal of Clinical Pharmacology
JF - The Journal of Clinical Pharmacology
IS - 8
ER -