Parkinson’s disease in 65 pairs of twins and in a set of quadruplets

Christopher D. Ward; Roger C. Duvoisin; Susan E. Ince; John D. Nutt; Roswell Eldridge; Donald B. Calne

doi:10.1212/wnl.33.7.815

Parkinson’s disease in 65 pairs of twins and in a set of quadruplets

Christopher D. Ward, Roger C. Duvoisin, Susan E. Ince, John D. Nutt, Roswell Eldridge, Donald B. Calne

Neurology

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332 Scopus citations

Abstract

Among 43 monozygotic (MZ) and 19 dizygotic (DZ) pairs in which an index case had definite Parkinson’s disease (PD), only one MZ pair was definitely concordant for PD. When pairs with questionable clinical features were included, 4 of 48 MZ and 1 of 19 DZ pairs were concordant. The frequency of PD in MZ cotwins of index cases with PD was similar to that expected in an unrelated control group matched for age and sex. Although we were unable to identify a single environmental agent, we conclude that the major factors in the etiology of PD are nongenetic.

Original language	English (US)
Pages (from-to)	815-824
Number of pages	10
Journal	Neurology
Volume	33
Issue number	7
DOIs	https://doi.org/10.1212/wnl.33.7.815
State	Published - Jul 1983

ASJC Scopus subject areas

Clinical Neurology

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AU - Duvoisin, Roger C.

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AU - Nutt, John D.

AU - Eldridge, Roswell

AU - Calne, Donald B.

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AB - Among 43 monozygotic (MZ) and 19 dizygotic (DZ) pairs in which an index case had definite Parkinson’s disease (PD), only one MZ pair was definitely concordant for PD. When pairs with questionable clinical features were included, 4 of 48 MZ and 1 of 19 DZ pairs were concordant. The frequency of PD in MZ cotwins of index cases with PD was similar to that expected in an unrelated control group matched for age and sex. Although we were unable to identify a single environmental agent, we conclude that the major factors in the etiology of PD are nongenetic.

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Parkinson’s disease in 65 pairs of twins and in a set of quadruplets

Abstract

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