Pathogenesis of HIV Encephalitis

Clayton A. Wiley, Rachel D. Schrier, Mitchel Morey, Christian Achim, J. Clark Venable, Jay A. Nelson

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A wide spectrum of infectious agents attack the central nervous system (CNS) of acquired immunodeficiency syndrome (AIDS) patients. Human immunodeficiency virus (HIV) itself, infects the CNS of a subgroup of these patients. The mechanism behind why HIV enters the CNS is unclear. We have observed an interesting association between HIV and opportunistic viral infections that may explain why HIV enters the brain. Infection of the CNS by opportunistic agents results in recruitment of latently HIV infected monocytes. Upon differentiation into macrophages these cells produce abundant HIV. Latent HIV‐infection of monocytes/macrophages provides a unique opportunity for cooperativity between opportunistic infections and HIV in mediating CNS damage.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalPathology International
Issue number3
StatePublished - Mar 1991
Externally publishedYes


  • HIV encephalitis
  • Mechanism of HIV ingress
  • Opportunistic viral infection

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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