Patient- and physician-level determinants of blood pressure response to treatment in normal weight and overweight patients (the PREVIEW study)

I. Abraham, K. MacDonald, M. Song, G. Ciesielski, C. Pacheco, C. Lee, M. Cholette, K. Kinsey, P. Speaks, C. Hermans, H. Brié, S. Reel, P. Van der Niepen, B. Yee, S. Vancayzeele

Research output: Contribution to journalArticlepeer-review


Background and aims: Obesity combined with hypertension places patients at greater risk for target-organ damage and cardiovascular disease. The purpose of this secondary analysis was to identify physician- and patient-levels determinants of blood pressure (BP) values and predictors of uncontrolled BP through subgroup analysis by body mass index (BMI). Methods and results: We conducted a subgroup analysis of 3006 patients with High-BMI (BMI >25kg/m2; n=2124) and Normal-BMI (BMI<25kg/m2; n=882) treated by 504 physicians and enrolled in PREVIEW, a Belgian prospective, multi-center, pharmaco-epidemiological study of 90-day second-line treatment with valsartan. Physician- and patient-level determinants of BP values and BP control were identified by means of hierarchical linear and logistic regression. Blood pressure values and control after 90 days of treatment were consistently lower for the High-BMI group. The 25.5% of variance in 90-day systolic and 28.3% of the variance in 90-day diastolic BP were attributable to physician-level determinants for the High-BMI group; versus 27.3% and 29.8% for the Normal-BMI group (ICC = 0.273 and 0.298, respectively). Determinants of 90-day BP values and predictors of uncontrolled BP varied considerably by BMI status. Conclusion: Several common and unique patient- and physician-level determinants of BP values and control were identified for the High-BMI and Normal-BMI groups. These findings highlight the need for differentiating healthcare interventions to account for patient and physician variables, particularly with respect to effective BP management in vulnerable populations.

Original languageEnglish (US)
Pages (from-to)314-322
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Issue number4
StatePublished - Apr 2013
Externally publishedYes


  • Angiotensin II receptor blocker
  • Body mass index
  • Effectiveness
  • Hypertension
  • Obesity
  • Pharmacoepidemiology
  • Valsartan

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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