Pediatric neurocritical care in the 21st century: From empiricism to evidence

Mark S. Wainwright, Gregory Hansen, Juan Piantino

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Purpose of review: Approximately one in five children admitted to a pediatric ICU have a new central nervous system injury or a neurological complication of their critical illness. The spectrum of neurologic insults in children is diverse and clinical practice is largely empirical, as few randomized, controlled trials have been reported. This lack of data poses a substantial challenge to the practice of pediatric neurocritical care (PNCC). PNCC has emerged as a novel subspecialty, and its presence is expanding within tertiary care centers. This review highlights the recent advances in the field, with a focus on traumatic brain injury (TBI), cardiac arrest, and stroke as disease models. Recent findings: Variable approaches to the structure of a PNCC service have been reported, comprising multidisciplinary teams from neurology, critical care, neurosurgery, neuroradiology, and anesthesia. Neurologic morbidity is substantial in critically ill children and the increased use of continuous electroencephalography monitoring has highlighted this burden. Therapeutic hypothermia has not proven effective for treatment of children with severe TBI or out-of-hospital cardiac arrest. However, results of studies of severe TBI suggest that multidisciplinary care in the ICU and adherence to guidelines for care can reduce mortality and improve outcome. Summary: There is an unmet need for clinicians with expertise in the practice of brain-directed critical care for children. Although much of the practice of PNCC may remain empiric, a focus on the regionalization of care, creating defined training paths, practice within multidisciplinary teams, protocol-directed care, and improved measures of long-term outcome to quantify the impact of such care can provide evidence to direct the maturation of this field.

Original languageEnglish (US)
Pages (from-to)106-112
Number of pages7
JournalCurrent Opinion in Critical Care
Issue number2
StatePublished - Apr 1 2016


  • cardiac arrest
  • neuromonitoring
  • stroke
  • traumatic brain injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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