“Per protocol” practice patterns for Children's Oncology Group trials within the radiation oncology community

Kevin X. Liu; Lubna Hammoudeh; Daphne A. Haas-Kogan; Stephanie A. Terezakis

doi:10.1002/pbc.29673

“Per protocol” practice patterns for Children's Oncology Group trials within the radiation oncology community

Kevin X. Liu, Lubna Hammoudeh, Daphne A. Haas-Kogan, Stephanie A. Terezakis

Research output: Contribution to journal › Article › peer-review

Abstract

Little is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimens. We conducted a 12-question survey of 358 pediatric radiation oncologists to characterize practice patterns regarding ongoing and completed COG protocols off study. With 130 responses (40.3%), the prevalence of providing treatment per protocol, but off study, before data are available in abstract or peer-reviewed form varied from 9.1% (for ACNS1422) to 88.1% (for AHOD1331). Future studies are needed to understand the effects of these practice patterns on outcomes.

Original language	English (US)
Article number	e29673
Journal	Pediatric Blood and Cancer
Volume	70
Issue number	8
DOIs	https://doi.org/10.1002/pbc.29673
State	Published - Aug 2023
Externally published	Yes

Keywords

Ewing sarcoma
Hodgkin lymphoma
ependymoma
medulloblastoma
neuroblastoma
rhabdomyosarcoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.29673

Cite this

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title = "“Per protocol” practice patterns for Children's Oncology Group trials within the radiation oncology community",

abstract = "Little is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimens. We conducted a 12-question survey of 358 pediatric radiation oncologists to characterize practice patterns regarding ongoing and completed COG protocols off study. With 130 responses (40.3%), the prevalence of providing treatment per protocol, but off study, before data are available in abstract or peer-reviewed form varied from 9.1% (for ACNS1422) to 88.1% (for AHOD1331). Future studies are needed to understand the effects of these practice patterns on outcomes.",

keywords = "Ewing sarcoma, Hodgkin lymphoma, ependymoma, medulloblastoma, neuroblastoma, rhabdomyosarcoma",

author = "Liu, {Kevin X.} and Lubna Hammoudeh and Haas-Kogan, {Daphne A.} and Terezakis, {Stephanie A.}",

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AU - Terezakis, Stephanie A.

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“Per protocol” practice patterns for Children's Oncology Group trials within the radiation oncology community

Abstract

Keywords

ASJC Scopus subject areas

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