@article{77c85b71d8524e038b22a1805d77b009,
title = "Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain",
abstract = "Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.",
keywords = "action potential, computational modeling, conduction velocity, myelin, node of Ranvier, oligodendrocyte, periaxonal space, plasticity, spatial learning, transcranial magnetic stimulation",
author = "Cullen, {Carlie L.} and Pepper, {Renee E.} and Clutterbuck, {Mackenzie T.} and Pitman, {Kimberley A.} and Viola Oorschot and Loic Auderset and Tang, {Alexander D.} and Georg Ramm and Ben Emery and Jennifer Rodger and Jolivet, {Renaud B.} and Young, {Kaylene M.}",
note = "Funding Information: We thank Dr. Rowan Tweedale (the University of Queensland) for constructive feedback on the manuscript. We thank Dr. Lee Cossell and Prof. David Attwell (University College London) for advice on computational modeling and Dr. Carola Thoni and Shane Rix (Lastek: Photonics Technology Solutions, Australia) for assistance with STED imaging. This research was supported by grants from the National Health and Medical Research Council of Australia (NHMRC) (1077792 and 1139041), MS Research Australia (11-014, 16-105, and 17-007), the Australian Research Council (DP180101494), the Medical Research Future Fund (EPCD08), the Swiss National Science Foundation (31003A_170079), and the National MS Society. Fellowships were awarded to C.L.C. (MS Research Australia and the Penn Foundation, 15-054), K.A.P. (NHMRC, 1139180), B.E. (NHMRC, 1032833; Warren endowed professorship in neuroscience research), K.M.Y. (NHMRC, 1045240; MS Research Australia/Macquarie Group Foundation, 17-0223), and J.R. (NHMRC, 1002258; the Perron Institute for Neurological and Translational Science; and MS Western Australia). Scholarships were awarded to L.A. (Australian Postgraduate Award) and to M.T.C. and R.E.P. (Menzies Institute for Medical Research, University of Tasmania). C.L.C. K.M.Y. R.B.J. R.E.P. K.A.P. J.R. and B.E. developed the project and wrote the manuscript. C.L.C. R.E.P. K.A.P. M.T.C. L.A. V.O. R.B.J. and K.M.Y. carried out the experiments. K.M.Y. J.R. C.L.C. B.E. and R.B.J. obtained the funding. C.L.C. R.E.P. M.T.C. and R.B.J. performed the statistical analyses and generated the figures. K.M.Y. A.D.T. G.R. J.R. and C.L.C. provided supervision. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2021",
month = jan,
day = "19",
doi = "10.1016/j.celrep.2020.108641",
language = "English (US)",
volume = "34",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}