Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

Carlie L. Cullen; Renee E. Pepper; Mackenzie T. Clutterbuck; Kimberley A. Pitman; Viola Oorschot; Loic Auderset; Alexander D. Tang; Georg Ramm; Ben Emery; Jennifer Rodger; Renaud B. Jolivet; Kaylene M. Young

doi:10.1016/j.celrep.2020.108641

Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

Carlie L. Cullen, Renee E. Pepper, Mackenzie T. Clutterbuck, Kimberley A. Pitman, Viola Oorschot, Loic Auderset, Alexander D. Tang, Georg Ramm, Ben Emery, Jennifer Rodger, Renaud B. Jolivet, Kaylene M. Young

Neurology

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.

Original language	English (US)
Article number	108641
Journal	Cell Reports
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.108641
State	Published - Jan 19 2021

Keywords

action potential
computational modeling
conduction velocity
myelin
node of Ranvier
oligodendrocyte
periaxonal space
plasticity
spatial learning
transcranial magnetic stimulation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108641

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title = "Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain",

abstract = "Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.",

keywords = "action potential, computational modeling, conduction velocity, myelin, node of Ranvier, oligodendrocyte, periaxonal space, plasticity, spatial learning, transcranial magnetic stimulation",

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AU - Cullen, Carlie L.

AU - Pepper, Renee E.

AU - Clutterbuck, Mackenzie T.

AU - Pitman, Kimberley A.

AU - Oorschot, Viola

AU - Auderset, Loic

AU - Tang, Alexander D.

AU - Ramm, Georg

AU - Emery, Ben

AU - Rodger, Jennifer

AU - Jolivet, Renaud B.

AU - Young, Kaylene M.

PY - 2021/1/19

Y1 - 2021/1/19

N2 - Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.

AB - Cullen et al. show that mature brain cells, called oligodendrocytes, undergo ultrastructural changes during learning. They lengthen the nodes of Ranvier and compress the periaxonal space to speed up action potential conduction. They also report that faster information transfer speeds correlate with greater skill acquisition during learning.

KW - action potential

KW - computational modeling

KW - conduction velocity

KW - myelin

KW - node of Ranvier

KW - oligodendrocyte

KW - periaxonal space

KW - plasticity

KW - spatial learning

KW - transcranial magnetic stimulation

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JO - Cell Reports

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Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain

Abstract

Keywords

ASJC Scopus subject areas

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