Perinatal outcomes of twin-to-twin transfusion syndrome associated with evidence of twin anemia polycythemia using different standardized definitions

Ahmed A. Nassr; McKenna Gessner; Shayan Mostafaei; Kamran Hessami; Jimmy Espinoza; Roopali V. Donepudi; Magdalena Sanz Cortes; Eyal Krispin; Raphael C. Sun; Shohra Qaderi; Ozhan M. Turan; Hiba J. Mustafa; Christopher Harman; Michael A. Belfort; Alireza A. Shamshirsaz

doi:10.1016/j.ejogrb.2022.10.007

Perinatal outcomes of twin-to-twin transfusion syndrome associated with evidence of twin anemia polycythemia using different standardized definitions

Ahmed A. Nassr, McKenna Gessner, Shayan Mostafaei, Kamran Hessami, Jimmy Espinoza, Roopali V. Donepudi, Magdalena Sanz Cortes, Eyal Krispin, Raphael C. Sun, Shohra Qaderi, Ozhan M. Turan, Hiba J. Mustafa, Christopher Harman, Michael A. Belfort, Alireza A. Shamshirsaz

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objectives: To evaluate the survival of twin-to-twin transfusion syndrome (TTTS) and concomitant twin anemia polycythemia sequence (TAPS) compared to TTTS without TAPS at the time of fetoscopic laser photocoagulation (FLP). Methods: TTTS pregnancies undergoing FLP were divided to three groups including (i) traditional TAPS definition of middle cerebral artery (MCA) peak systolic velocity (PSV) < 1 multiple of the median (MoM) in recipient and > 1.5 MoM in the donor fetus, (ii) delta MCA-PSV > 0.5 MoM and (iii) delta MCA-PSV > 1.0 MoM. Results: A total of 353 monochorionic twins underwent FLP for TTTS. Based on the traditional definition, 335 (94.9 %) had TTTS only and 18 (5.1 %) had TTTS + TAPS. There were 245 (69.4 %) TTTS only and 108 (30.6 %) TTTS + TAPS considering delta MCA-PSV > 0.5 MoM and 339 (96 %) TTTS only and 14 (4 %) TTTS + TAPS considering delta MCA-PSV > 1.0 MoM. No significant differences in survival were noted at birth or 30-days after delivery between TTTS and TTTS with TAPS patients using the traditional definition, delta > 0.5 MoM or delta > 1.0 MoM. Conclusion: The rate of neonatal survival at birth or at 30-days of life following FLP for TTTS only and TTTS with TAPS were not different based on any of the clinically used TAPS definitions.

Original language	English (US)
Pages (from-to)	45-49
Number of pages	5
Journal	European Journal of Obstetrics and Gynecology and Reproductive Biology
Volume	279
DOIs	https://doi.org/10.1016/j.ejogrb.2022.10.007
State	Published - Dec 2022
Externally published	Yes

Keywords

Doppler
Perinatal outcome
Twin anemia polycythemia sequence
Twin-to-twin transfusion syndrome

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1016/j.ejogrb.2022.10.007

Cite this

Nassr, A. A., Gessner, M., Mostafaei, S., Hessami, K., Espinoza, J., Donepudi, R. V., Sanz Cortes, M., Krispin, E., Sun, R. C., Qaderi, S., Turan, O. M., Mustafa, H. J., Harman, C., Belfort, M. A., & Shamshirsaz, A. A. (2022). Perinatal outcomes of twin-to-twin transfusion syndrome associated with evidence of twin anemia polycythemia using different standardized definitions. European Journal of Obstetrics and Gynecology and Reproductive Biology, 279, 45-49. https://doi.org/10.1016/j.ejogrb.2022.10.007

Perinatal outcomes of twin-to-twin transfusion syndrome associated with evidence of twin anemia polycythemia using different standardized definitions. / Nassr, Ahmed A.; Gessner, McKenna; Mostafaei, Shayan et al.
In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 279, 12.2022, p. 45-49.

Research output: Contribution to journal › Article › peer-review

Nassr, AA, Gessner, M, Mostafaei, S, Hessami, K, Espinoza, J, Donepudi, RV, Sanz Cortes, M, Krispin, E, Sun, RC, Qaderi, S, Turan, OM, Mustafa, HJ, Harman, C, Belfort, MA & Shamshirsaz, AA 2022, 'Perinatal outcomes of twin-to-twin transfusion syndrome associated with evidence of twin anemia polycythemia using different standardized definitions', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 279, pp. 45-49. https://doi.org/10.1016/j.ejogrb.2022.10.007

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title = "Perinatal outcomes of twin-to-twin transfusion syndrome associated with evidence of twin anemia polycythemia using different standardized definitions",

abstract = "Objectives: To evaluate the survival of twin-to-twin transfusion syndrome (TTTS) and concomitant twin anemia polycythemia sequence (TAPS) compared to TTTS without TAPS at the time of fetoscopic laser photocoagulation (FLP). Methods: TTTS pregnancies undergoing FLP were divided to three groups including (i) traditional TAPS definition of middle cerebral artery (MCA) peak systolic velocity (PSV) < 1 multiple of the median (MoM) in recipient and > 1.5 MoM in the donor fetus, (ii) delta MCA-PSV > 0.5 MoM and (iii) delta MCA-PSV > 1.0 MoM. Results: A total of 353 monochorionic twins underwent FLP for TTTS. Based on the traditional definition, 335 (94.9 %) had TTTS only and 18 (5.1 %) had TTTS + TAPS. There were 245 (69.4 %) TTTS only and 108 (30.6 %) TTTS + TAPS considering delta MCA-PSV > 0.5 MoM and 339 (96 %) TTTS only and 14 (4 %) TTTS + TAPS considering delta MCA-PSV > 1.0 MoM. No significant differences in survival were noted at birth or 30-days after delivery between TTTS and TTTS with TAPS patients using the traditional definition, delta > 0.5 MoM or delta > 1.0 MoM. Conclusion: The rate of neonatal survival at birth or at 30-days of life following FLP for TTTS only and TTTS with TAPS were not different based on any of the clinically used TAPS definitions.",

keywords = "Doppler, Perinatal outcome, Twin anemia polycythemia sequence, Twin-to-twin transfusion syndrome",

author = "Nassr, {Ahmed A.} and McKenna Gessner and Shayan Mostafaei and Kamran Hessami and Jimmy Espinoza and Donepudi, {Roopali V.} and {Sanz Cortes}, Magdalena and Eyal Krispin and Sun, {Raphael C.} and Shohra Qaderi and Turan, {Ozhan M.} and Mustafa, {Hiba J.} and Christopher Harman and Belfort, {Michael A.} and Shamshirsaz, {Alireza A.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = dec,

doi = "10.1016/j.ejogrb.2022.10.007",

language = "English (US)",

volume = "279",

pages = "45--49",

journal = "European Journal of Obstetrics and Gynecology and Reproductive Biology",

issn = "0301-2115",

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TY - JOUR

T1 - Perinatal outcomes of twin-to-twin transfusion syndrome associated with evidence of twin anemia polycythemia using different standardized definitions

AU - Nassr, Ahmed A.

AU - Gessner, McKenna

AU - Mostafaei, Shayan

AU - Hessami, Kamran

AU - Espinoza, Jimmy

AU - Donepudi, Roopali V.

AU - Sanz Cortes, Magdalena

AU - Krispin, Eyal

AU - Sun, Raphael C.

AU - Qaderi, Shohra

AU - Turan, Ozhan M.

AU - Mustafa, Hiba J.

AU - Harman, Christopher

AU - Belfort, Michael A.

AU - Shamshirsaz, Alireza A.

PY - 2022/12

Y1 - 2022/12

N2 - Objectives: To evaluate the survival of twin-to-twin transfusion syndrome (TTTS) and concomitant twin anemia polycythemia sequence (TAPS) compared to TTTS without TAPS at the time of fetoscopic laser photocoagulation (FLP). Methods: TTTS pregnancies undergoing FLP were divided to three groups including (i) traditional TAPS definition of middle cerebral artery (MCA) peak systolic velocity (PSV) < 1 multiple of the median (MoM) in recipient and > 1.5 MoM in the donor fetus, (ii) delta MCA-PSV > 0.5 MoM and (iii) delta MCA-PSV > 1.0 MoM. Results: A total of 353 monochorionic twins underwent FLP for TTTS. Based on the traditional definition, 335 (94.9 %) had TTTS only and 18 (5.1 %) had TTTS + TAPS. There were 245 (69.4 %) TTTS only and 108 (30.6 %) TTTS + TAPS considering delta MCA-PSV > 0.5 MoM and 339 (96 %) TTTS only and 14 (4 %) TTTS + TAPS considering delta MCA-PSV > 1.0 MoM. No significant differences in survival were noted at birth or 30-days after delivery between TTTS and TTTS with TAPS patients using the traditional definition, delta > 0.5 MoM or delta > 1.0 MoM. Conclusion: The rate of neonatal survival at birth or at 30-days of life following FLP for TTTS only and TTTS with TAPS were not different based on any of the clinically used TAPS definitions.

AB - Objectives: To evaluate the survival of twin-to-twin transfusion syndrome (TTTS) and concomitant twin anemia polycythemia sequence (TAPS) compared to TTTS without TAPS at the time of fetoscopic laser photocoagulation (FLP). Methods: TTTS pregnancies undergoing FLP were divided to three groups including (i) traditional TAPS definition of middle cerebral artery (MCA) peak systolic velocity (PSV) < 1 multiple of the median (MoM) in recipient and > 1.5 MoM in the donor fetus, (ii) delta MCA-PSV > 0.5 MoM and (iii) delta MCA-PSV > 1.0 MoM. Results: A total of 353 monochorionic twins underwent FLP for TTTS. Based on the traditional definition, 335 (94.9 %) had TTTS only and 18 (5.1 %) had TTTS + TAPS. There were 245 (69.4 %) TTTS only and 108 (30.6 %) TTTS + TAPS considering delta MCA-PSV > 0.5 MoM and 339 (96 %) TTTS only and 14 (4 %) TTTS + TAPS considering delta MCA-PSV > 1.0 MoM. No significant differences in survival were noted at birth or 30-days after delivery between TTTS and TTTS with TAPS patients using the traditional definition, delta > 0.5 MoM or delta > 1.0 MoM. Conclusion: The rate of neonatal survival at birth or at 30-days of life following FLP for TTTS only and TTTS with TAPS were not different based on any of the clinically used TAPS definitions.

KW - Doppler

KW - Perinatal outcome

KW - Twin anemia polycythemia sequence

KW - Twin-to-twin transfusion syndrome

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U2 - 10.1016/j.ejogrb.2022.10.007

DO - 10.1016/j.ejogrb.2022.10.007

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AN - SCOPUS:85139848625

SN - 0301-2115

VL - 279

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JO - European Journal of Obstetrics and Gynecology and Reproductive Biology

JF - European Journal of Obstetrics and Gynecology and Reproductive Biology

ER -

Perinatal outcomes of twin-to-twin transfusion syndrome associated with evidence of twin anemia polycythemia using different standardized definitions

Abstract

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