Pernicious anemia: Fundamental and practical aspects in diagnosis

Aung Myint Tun; Kyaw Zin Thein; Zin War Myint; Thein Hlaing Oo

doi:10.2174/1871525715666170203114632

Pernicious anemia: Fundamental and practical aspects in diagnosis

Aung Myint Tun, Kyaw Zin Thein, Zin War Myint, Thein Hlaing Oo

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Background: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations. Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.

Original language	English (US)
Pages (from-to)	17-22
Number of pages	6
Journal	Cardiovascular and Hematological Agents in Medicinal Chemistry
Volume	15
Issue number	1
DOIs	https://doi.org/10.2174/1871525715666170203114632
State	Published - Apr 1 2017
Externally published	Yes

Keywords

Cobalamia deficiency
Diagnostic challenges
Fundamental aspects
Pathophysiology
Pernicious anemia
Practical approach

ASJC Scopus subject areas

Hematology
Pharmacology
Cardiology and Cardiovascular Medicine

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10.2174/1871525715666170203114632

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title = "Pernicious anemia: Fundamental and practical aspects in diagnosis",

abstract = "Background: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations. Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.",

keywords = "Cobalamia deficiency, Diagnostic challenges, Fundamental aspects, Pathophysiology, Pernicious anemia, Practical approach",

author = "Tun, {Aung Myint} and Thein, {Kyaw Zin} and Myint, {Zin War} and Oo, {Thein Hlaing}",

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T1 - Pernicious anemia

T2 - Fundamental and practical aspects in diagnosis

AU - Tun, Aung Myint

AU - Thein, Kyaw Zin

AU - Myint, Zin War

AU - Oo, Thein Hlaing

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Background: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations. Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.

AB - Background: Pernicious Anemia (PA), the most common cause of cobalamin deficiency anemia worldwide, is an autoimmune disease of multifactorial etiologies involving complex environmental and immunological factors. Although it was first reported by Addison in 1849 with subsequent advances in understanding of pathogenesis and molecular biology, diagnosis of PA is still challenging for clinicians because of its complexity and diverse clinical presentations. Conclusion: Herein, we provide an overview of PA, mainly focusing on its scientific and practical aspects in diagnosis. We also discuss the limitations of currently available diagnostic tools for the evaluation of cobalamin deficiency and PA.

KW - Cobalamia deficiency

KW - Diagnostic challenges

KW - Fundamental aspects

KW - Pathophysiology

KW - Pernicious anemia

KW - Practical approach

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Pernicious anemia: Fundamental and practical aspects in diagnosis

Abstract

Keywords

ASJC Scopus subject areas

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