TY - JOUR
T1 - Perspective
T2 - Council for Responsible Nutrition Science in Session. Optimizing Health with Nutrition—Opportunities, Gaps, and the Future
AU - Ho, Emily
AU - Drake, Victoria J.
AU - Michels, Alexander J.
AU - Nkrumah-Elie, Yasmeen M.
AU - Brown, La Verne L.
AU - Scott, Jonathan M.
AU - Newman, John W.
AU - Shukitt-Hale, Barbara
AU - Soumyanath, Amala
AU - Chilton, Floyd H.
AU - Lindemann, Stephen R.
AU - Shao, Andrew
AU - Mitmesser, Susan Hazels
N1 - Publisher Copyright:
© 2023
PY - 2023/9
Y1 - 2023/9
N2 - Achieving optimal health is an aspirational goal for the population, yet the definition of health remains unclear. The role of nutrition in health has evolved beyond correcting malnutrition and specific deficiencies and has begun to focus more on achieving and maintaining ‘optimal’ health through nutrition. As such, the Council for Responsible Nutrition held its October 2022 Science in Session conference to advance this concept. Here, we summarize and discuss the findings of their Optimizing Health through Nutrition – Opportunities and Challenges workshop, including several gaps that need to be addressed to advance progress in the field. Defining and evaluating various indices of optimal health will require overcoming these key gaps. For example, there is a strong need to develop better biomarkers of nutrient status, including more accurate markers of food intake, as well as biomarkers of optimal health that account for maintaining resilience—the ability to recover from or respond to stressors without loss to physical and cognitive performance. In addition, there is a need to identify factors that drive individualized responses to nutrition, including genotype, metabotypes, and the gut microbiome, and to realize the opportunity of precision nutrition for optimal health. This review outlines hallmarks of resilience, provides current examples of nutritional factors to optimize cognitive and performance resilience, and gives an overview of various genetic, metabolic, and microbiome determinants of individualized responses.
AB - Achieving optimal health is an aspirational goal for the population, yet the definition of health remains unclear. The role of nutrition in health has evolved beyond correcting malnutrition and specific deficiencies and has begun to focus more on achieving and maintaining ‘optimal’ health through nutrition. As such, the Council for Responsible Nutrition held its October 2022 Science in Session conference to advance this concept. Here, we summarize and discuss the findings of their Optimizing Health through Nutrition – Opportunities and Challenges workshop, including several gaps that need to be addressed to advance progress in the field. Defining and evaluating various indices of optimal health will require overcoming these key gaps. For example, there is a strong need to develop better biomarkers of nutrient status, including more accurate markers of food intake, as well as biomarkers of optimal health that account for maintaining resilience—the ability to recover from or respond to stressors without loss to physical and cognitive performance. In addition, there is a need to identify factors that drive individualized responses to nutrition, including genotype, metabotypes, and the gut microbiome, and to realize the opportunity of precision nutrition for optimal health. This review outlines hallmarks of resilience, provides current examples of nutritional factors to optimize cognitive and performance resilience, and gives an overview of various genetic, metabolic, and microbiome determinants of individualized responses.
KW - cognition
KW - individual metabolic variability
KW - microbiome
KW - nutrient–gene interactions
KW - nutrition
KW - optimal health
KW - precision health
KW - resilience
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U2 - 10.1016/j.advnut.2023.05.015
DO - 10.1016/j.advnut.2023.05.015
M3 - Article
C2 - 37270030
AN - SCOPUS:85162886494
SN - 2161-8313
VL - 14
SP - 948
EP - 958
JO - Advances in Nutrition
JF - Advances in Nutrition
IS - 5
ER -