Pharmacological therapies in fibromylagia

Srinivas G. Rao, Robert M. Bennett

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


The fibromyalgia syndrome (FMS) is a common, chronic, widespread pain disorder that mainly affects middle-aged women. In addition to pain complaints, fatigue and disturbed sleep are symptoms frequently reported by these patients. Many FMS patients also meet diagnostic criteria for mood disorders (e.g. depression) as well as other so-called 'functional somatic syndromes', including irritable bowel syndrome, temporomandibular joint disorder, and subsets of chronic low-back pain. A wide variety of medications are used to manage the eclectic symptomatology of FMS patients, although relatively few have been rigorously tested. This chapter provides a contemporary update of the state of FMS pharmacotherapy, with an emphasis on compounds that have been tested in double-blind, randomized, controlled trials. Particular attention is paid to the efficacy of these therapies on the associated symptoms and co-morbid syndromes commonly seen in FMS patients.

Original languageEnglish (US)
Pages (from-to)611-627
Number of pages17
JournalBest Practice and Research: Clinical Rheumatology
Issue number4
StatePublished - Aug 2003
Externally publishedYes


  • Anti-epileptic
  • Antidepressants
  • Fatigue
  • Fibromyalgia
  • Growth hormone
  • Hypnotic
  • NMDA
  • Noradrenaline
  • Norepineph rine
  • Opiate
  • Pain
  • Sedative
  • Serotonin
  • Sleep

ASJC Scopus subject areas

  • Rheumatology


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