Physical association of PDK1 with AKT1 Is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase

Medicine & Life Sciences

• 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine 10%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 7%
• 3-Phosphoinositide-Dependent Protein Kinases 100%
• Cell Membrane 8%
• Drug Delivery Systems 5%
• Mechanistic Target of Rapamycin Complex 1 7%
• Membranes 35%
• Neoplasms 1%
• Phosphates 5%
• Phosphatidylinositol 3-Kinase 60%
• Phosphorylation 20%
• Phosphotransferases 4%
• PI103 11%
• Pleckstrin Homology Domains 8%
• Protein-Serine-Threonine Kinases 6%
• Proteins 2%
• Sirolimus 6%
• Therapeutics 2%
• Threonine 20%

Agriculture & Biology

• cell membranes 9%
• cells 1%
• drugs 3%
• fluorescent proteins 6%
• loci 3%
• mutants 3%
• neoplasms 4%
• phosphates 3%
• phosphatidylinositol 3-kinase 78%
• phosphorylation 23%
• phosphotransferases (kinases) 51%
• rapamycin 7%
• species recruitment 4%
• therapeutics 8%

Chemical Compounds

• Drug 6%
• LY294002 22%
• Phosphatidylinositol 72%
• Phosphatidylinositol 3 Kinase Inhibitor 20%
• Protein 4%
• Resistance 15%
• Surface 3%
• Threonine 40%