Abstract
Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.
Original language | English (US) |
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Pages (from-to) | 4085-4089 |
Number of pages | 5 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 106 |
Issue number | 11 |
DOIs | |
State | Published - Mar 17 2009 |
Externally published | Yes |
Keywords
- Dual-modality imaging
- Ferromagnetic nanoparticle molecular imaging
- MRI contrast
- Photoacoustic tomography
ASJC Scopus subject areas
- General