TY - JOUR
T1 - Platelets and von Willebrand factor in atherogenesis
AU - Wu, Melinda D.
AU - Atkinson, Tamara M.
AU - Lindner, Jonathan R.
N1 - Funding Information:
This work was supported by grants R01-HL078610, R01-HL111969, and R01-HL120046 (J.R.L.), T32-HL094294 (M.D.W. and T.M.A.), and K08-HL133493 (M.D.W.) from the National Heart, Lung, and Blood Institute of the National Institutes of Health, and 14-14NSBRI1-0025 from the National Space Biomedical Research Institute (J.R.L.).
Publisher Copyright:
Copyright © 2011 by The American Society of Hematology; all rights reserved.
PY - 2017/3/16
Y1 - 2017/3/16
N2 - The role of platelet adhesion, activation, and aggregation in acute atherothrombotic events such as myocardial infarction and strokeis wellestablished. Thereis increasing evidence that platelet-endothelial interactions also contribute to early atherosclerotic plaque initiation and growth. Through these interactions, platelet-derived factors can contribute to the proinflammatory and mitogenic status of resident mural cells. Among the many putative mechanisms for platelet-endothelial interactions, increased endothelial-associated von Willebrand factor, particularly in a multimerized form, which interacts with platelet glycoproteins and integrins, is a major factor and represents a therapeutic target in early atherogenesis.
AB - The role of platelet adhesion, activation, and aggregation in acute atherothrombotic events such as myocardial infarction and strokeis wellestablished. Thereis increasing evidence that platelet-endothelial interactions also contribute to early atherosclerotic plaque initiation and growth. Through these interactions, platelet-derived factors can contribute to the proinflammatory and mitogenic status of resident mural cells. Among the many putative mechanisms for platelet-endothelial interactions, increased endothelial-associated von Willebrand factor, particularly in a multimerized form, which interacts with platelet glycoproteins and integrins, is a major factor and represents a therapeutic target in early atherogenesis.
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U2 - 10.1182/blood-2016-07-692673
DO - 10.1182/blood-2016-07-692673
M3 - Article
C2 - 28174163
AN - SCOPUS:85015932250
SN - 0006-4971
VL - 129
SP - 1415
EP - 1419
JO - Blood
JF - Blood
IS - 11
ER -