Platelets and von Willebrand factor in atherogenesis

Melinda D. Wu, Tamara M. Atkinson, Jonathan R. Lindner

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


The role of platelet adhesion, activation, and aggregation in acute atherothrombotic events such as myocardial infarction and strokeis wellestablished. Thereis increasing evidence that platelet-endothelial interactions also contribute to early atherosclerotic plaque initiation and growth. Through these interactions, platelet-derived factors can contribute to the proinflammatory and mitogenic status of resident mural cells. Among the many putative mechanisms for platelet-endothelial interactions, increased endothelial-associated von Willebrand factor, particularly in a multimerized form, which interacts with platelet glycoproteins and integrins, is a major factor and represents a therapeutic target in early atherogenesis.

Original languageEnglish (US)
Pages (from-to)1415-1419
Number of pages5
Issue number11
StatePublished - Mar 16 2017

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology


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