TY - JOUR
T1 - PLTP activity decreases with weight loss
T2 - Changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity
AU - Murdoch, Susan J.
AU - Kahn, Steven E.
AU - Albers, John J.
AU - Brunzell, John D.
AU - Purnell, Jonathan Q.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Phospholipid transfer protein (PLTP) activity is elevated in obese and diabetic subjects. No prospective studies have examined the effect of weight loss on PLTP activity and assessed whether the resultant changes in activity are related to changes in body weight, insulin resistance, or both. PLTP activity was measured at baseline in 46 subjects (body mass index = 19-64 kg/m2) and after diet-induced weight loss in 19 of the obese subjects. Total body fat mass (FM) by dual-energy X-ray absorptiometry, intraabdominal fat (IAF), and abdominal subcutaneous fat (SQF) by CT scan, insulin sensitivity (SI) by frequently sampled intravenous glucose tolerance test, leptin, and lipids were determined. At baseline, PLTP activity correlated with FM (r = 0.36, P = 0.02) and SQF (r = 0.31, P = 0.045), but not with IAF (r = 0.16, P = 0.32) or SI (r = 0.10, P = 0.52). With diet-induced weight loss (16 ± 7.3 kg), PLTP activity significantly decreased 9.1% (P = 0.002). The change in PLTP activity correlated with the change in SQF (r = 0.55, P = 0.014) (33.6% decrease), but not with IAF (r = 0.09, P = 0.73) or SI (r = 0.18, P = 0.44), and was highly correlated with the change in nonesterified fatty acid (NEFA) (r = 0.71, P < 0.001). In conclusion, elevated PLTP activity in obese subjects is likely a result of increased body fat, reflected by SQF, and is influenced by NEFAs but is not directly related to insulin resistance.-Murdoch, S. J., S. E. Kahn, J. J. Albers, J. D. Brunzell, and J. Q. Purnell. PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity.
AB - Phospholipid transfer protein (PLTP) activity is elevated in obese and diabetic subjects. No prospective studies have examined the effect of weight loss on PLTP activity and assessed whether the resultant changes in activity are related to changes in body weight, insulin resistance, or both. PLTP activity was measured at baseline in 46 subjects (body mass index = 19-64 kg/m2) and after diet-induced weight loss in 19 of the obese subjects. Total body fat mass (FM) by dual-energy X-ray absorptiometry, intraabdominal fat (IAF), and abdominal subcutaneous fat (SQF) by CT scan, insulin sensitivity (SI) by frequently sampled intravenous glucose tolerance test, leptin, and lipids were determined. At baseline, PLTP activity correlated with FM (r = 0.36, P = 0.02) and SQF (r = 0.31, P = 0.045), but not with IAF (r = 0.16, P = 0.32) or SI (r = 0.10, P = 0.52). With diet-induced weight loss (16 ± 7.3 kg), PLTP activity significantly decreased 9.1% (P = 0.002). The change in PLTP activity correlated with the change in SQF (r = 0.55, P = 0.014) (33.6% decrease), but not with IAF (r = 0.09, P = 0.73) or SI (r = 0.18, P = 0.44), and was highly correlated with the change in nonesterified fatty acid (NEFA) (r = 0.71, P < 0.001). In conclusion, elevated PLTP activity in obese subjects is likely a result of increased body fat, reflected by SQF, and is influenced by NEFAs but is not directly related to insulin resistance.-Murdoch, S. J., S. E. Kahn, J. J. Albers, J. D. Brunzell, and J. Q. Purnell. PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity.
KW - Diabetes
KW - Free fatty acid
KW - Intraabdominal fat
KW - Leptin
KW - Obesity
KW - Phospholipid transfer protein
UR - http://www.scopus.com/inward/record.url?scp=0141682469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141682469&partnerID=8YFLogxK
U2 - 10.1194/jlr.M300073-JLR200
DO - 10.1194/jlr.M300073-JLR200
M3 - Article
C2 - 12837855
AN - SCOPUS:0141682469
SN - 0022-2275
VL - 44
SP - 1705
EP - 1712
JO - Journal of lipid research
JF - Journal of lipid research
IS - 9
ER -