TY - JOUR
T1 - Polarization-Diversity Optical Coherence Tomography Assessment of Choroidal Nevi
AU - Miao, Yusi
AU - Jung, Hoyoung
AU - Hsu, Destiny
AU - Song, Jun
AU - Ni, Shuibin
AU - Ma, Da
AU - Jian, Yifan
AU - Makita, Shuichi
AU - Yasuno, Yoshiaki
AU - Sarunic, Marinko V.
AU - Stephenson, Kirk A.J.
AU - Paton, Katherine
AU - Mammo, Zaid
AU - Ju, Myeong Jin
N1 - Publisher Copyright:
Copyright 2023 The Authors.
PY - 2023/11
Y1 - 2023/11
N2 - PURPOSE. The purpose of this study was to demonstrate the utility of polarization-diversity optical coherence tomography (PD-OCT), a noninvasive imaging technique with melanin-specific contrast, in the quantitative and qualitative assessment of choroidal nevi. METHODS. Nevi were imaged with a custom-built 55-degree field-of-view (FOV) 400 kHz PD-OCT system. Imaging features on PD-OCT were compared to those on fundus photography, auto-fluorescence, ultrasound, and non-PD-OCT images. Lesions were manually segmented for size measurement and metrics for objective assessment of melanin distributions were calculated, including degree of polarization uniformity (DOPU), attenuation coefficient, and melanin occupancy rate (MOR). RESULTS. We imaged 17 patients (mean age = 69.5 years, range = 37–90) with 11 pigmented, 3 non-pigmented, and 3 mixed pigmentation nevi. Nevi with full margin acquisition had an average longest basal diameter of 5.1 mm (range = 2.99–8.72 mm) and average height of 0.72 mm (range = 0.37 mm–2.09 mm). PD-OCT provided clear contrast of choroidal melanin content, distribution, and delineation of nevus margins for melanotic nevi. Pigmented nevi were found to have lower DOPU, higher attenuation coefficient, and higher MOR than non-pigmented lesions. Melanin content on PD-OCT was consistent with pigmentation on fundus in 15 of 17 nevi (88%). CONCLUSIONS. PD-OCT allows objective assessment of choroidal nevi melanin content and distribution. In addition, melanin-specific contrast by PD-OCT enables clear nevus margin delineation and may improve serial growth surveillance. Further investigation is needed to determine the clinical significance and prognostic value of melanin characterization by PD-OCT in the evaluation of choroidal nevi.
AB - PURPOSE. The purpose of this study was to demonstrate the utility of polarization-diversity optical coherence tomography (PD-OCT), a noninvasive imaging technique with melanin-specific contrast, in the quantitative and qualitative assessment of choroidal nevi. METHODS. Nevi were imaged with a custom-built 55-degree field-of-view (FOV) 400 kHz PD-OCT system. Imaging features on PD-OCT were compared to those on fundus photography, auto-fluorescence, ultrasound, and non-PD-OCT images. Lesions were manually segmented for size measurement and metrics for objective assessment of melanin distributions were calculated, including degree of polarization uniformity (DOPU), attenuation coefficient, and melanin occupancy rate (MOR). RESULTS. We imaged 17 patients (mean age = 69.5 years, range = 37–90) with 11 pigmented, 3 non-pigmented, and 3 mixed pigmentation nevi. Nevi with full margin acquisition had an average longest basal diameter of 5.1 mm (range = 2.99–8.72 mm) and average height of 0.72 mm (range = 0.37 mm–2.09 mm). PD-OCT provided clear contrast of choroidal melanin content, distribution, and delineation of nevus margins for melanotic nevi. Pigmented nevi were found to have lower DOPU, higher attenuation coefficient, and higher MOR than non-pigmented lesions. Melanin content on PD-OCT was consistent with pigmentation on fundus in 15 of 17 nevi (88%). CONCLUSIONS. PD-OCT allows objective assessment of choroidal nevi melanin content and distribution. In addition, melanin-specific contrast by PD-OCT enables clear nevus margin delineation and may improve serial growth surveillance. Further investigation is needed to determine the clinical significance and prognostic value of melanin characterization by PD-OCT in the evaluation of choroidal nevi.
KW - choroidal melanoma
KW - choroidal nevi
KW - optical coherence tomography (OCT)
KW - polarization
UR - http://www.scopus.com/inward/record.url?scp=85176404560&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85176404560&partnerID=8YFLogxK
U2 - 10.1167/iovs.64.14.6
DO - 10.1167/iovs.64.14.6
M3 - Article
C2 - 37930688
AN - SCOPUS:85176404560
SN - 0146-0404
VL - 64
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 14
M1 - 6
ER -