Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury

Amy E.B. Packard; Jason C. Hedges; Frances R. Bahjat; Susan L. Stevens; Michael J. Conlin; Andres M. Salazar; Mary P. Stenzel-Poore

doi:10.1038/jcbfm.2011.160

Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury

Amy E.B. Packard, Jason C. Hedges, Frances R. Bahjat, Susan L. Stevens, Michael J. Conlin, Andres M. Salazar, Mary P. Stenzel-Poore

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is a new powerful prophylactic treatment that offers promise as a clinical therapeutic strategy to minimize damage in patient populations at risk of ischemic injury.

Original language	English (US)
Pages (from-to)	242-247
Number of pages	6
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	32
Issue number	2
DOIs	https://doi.org/10.1038/jcbfm.2011.160
State	Published - Feb 2012

Keywords

cerebrovascular disease
focal ischemia
inflammation
ischemic preconditioning and induced tolerance
neuroprotection

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.2011.160

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title = "Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury",

abstract = "Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is a new powerful prophylactic treatment that offers promise as a clinical therapeutic strategy to minimize damage in patient populations at risk of ischemic injury.",

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AU - Conlin, Michael J.

AU - Salazar, Andres M.

AU - Stenzel-Poore, Mary P.

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AB - Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is a new powerful prophylactic treatment that offers promise as a clinical therapeutic strategy to minimize damage in patient populations at risk of ischemic injury.

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Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury

Abstract

Keywords

ASJC Scopus subject areas

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