Post-inhibitory rebound properties of dopaminergic cells of the ventral tegmental area

Kush Paul, Steven W. Johnson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We have investigated the post-inhibitory rebound (PIR) properties of dopamine cells in the ventral tegmental area of the rat midbrain. Using microelectrodes to record intracellularly from rat cells in the midbrain slice, we found that 54 % of all recorded DA cells exhibited rebound depolarization in the presence of TTX. We observed primarily two types of rebound responses distinguished by their maximum amplitude and inactivation time constant, which we have termed as the 'slowly inactivating PIR' and low-threshold spike (LTS). 35% of DA cells exhibited a 'slowly inactivating PIR' and 19% showed LTS. A subset of the latter exhibited repetitive LTS. The PIR was enhanced in high K+ medium and suppressed in low-calcium medium. Under voltage clamp conditions, inward rebound currents at the end of a hyperpolarizing voltage step were partially blocked by specific T-type channel blocker, Ni 2+. Repetitive LTSs were reversibly changed to single LTS by blocking the potassium SK current.

Original languageEnglish (US)
Pages (from-to)147-157
Number of pages11
JournalNeuroscience Research Communications
Issue number3
StatePublished - Nov 2003


  • Brain slice
  • Calcium channel
  • Dopamine
  • Midbrain
  • Post-inhibitory rebound
  • Ventral tegmental area

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Post-inhibitory rebound properties of dopaminergic cells of the ventral tegmental area'. Together they form a unique fingerprint.

Cite this