Precursors to rapid elevations in intracranial pressure

James McNames, Cristina Crespo, Mateo Aboy, Miles Ellenby, Susanna Lai, Robert Sclabassi, Brahm Goldstein

Research output: Contribution to journalConference articlepeer-review

9 Scopus citations


Intracranial pressure (ICP) monitoring and management have substantially improved the outcome of patients with traumatic brain injury (TBI). However, rapid elevations in ICP remain a significant problem as they may lead to secondary brain injury and worse outcome due to cerebral ischemia. Current therapy is targeted towards treating rapid ICP elevations after they occur. Ideally, anticipatory treatment to obviate any elevation in ICP could occur if reliable precursors to ICP elevation were determined. In this paper, we report evidence for a physiologic transition zone prior to rapid elevations in ICP. We found that in thirty-three episodes of ICP elevation recorded from eleven patients, there was a statistically consistent decrease in the cardiac component of the ICP signal and the coefficient of correlation between the ICP trend and the pulse amplitude. We conclude that specific ICP signal metrics may serve as precursors that characterize the transition zone prior to a rapid elevation and may enable prediction of these elevations up to thirty seconds ahead.

Original languageEnglish (US)
Pages (from-to)3977-3980
Number of pages4
JournalAnnual Reports of the Research Reactor Institute, Kyoto University
StatePublished - 2001
Externally publishedYes
Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Istanbul, Turkey
Duration: Oct 25 2001Oct 28 2001


  • Autoregulation
  • Cerebral perfussion pressure
  • Head injury
  • Intracranial hypertension
  • Intracranial pressure
  • Time series prediction
  • Traumatic brain injury

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Mechanical Engineering


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