TY - JOUR
T1 - Predictors of healthy brain aging
AU - Gonzales McNeal, Melissa Gonzales
AU - Zareparsi, Sepideh
AU - Camicioli, Richard
AU - Dame, Alison
AU - Howieson, Diane
AU - Quinn, Joseph
AU - Ball, Melvyn
AU - Kaye, Jeffrey
AU - Payami, Haydeh
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - To determine if superior health at old age protects against cognitive impairment (CI) and Alzheimer's disease (AD), we prospectively studied 100 optimally healthy oldest-old (85 years) individuals. Initially, subjects represented the top 3% of the oldest old for health. During 5.6 ± 0.3 years of follow-up, 34 subjects developed CI, and 23 progressed to AD. By age 100, probability of CI and AD were .65 ± .09 and .49 ± .10. Median onset age was 97 years for CI and 100 for AD. Clearly, superior health at old age does not guarantee protection against cognitive decline. Lifetime risks were similar to the general population but onset ages were later, suggesting factors that delay onset are key to improving cognitive health in the elderly. In this population, absence of apolipoprotein E-ε4 and male gender were associated with delayed onset, whereas estrogen use and education had no detectable effect on cognitive outcome.
AB - To determine if superior health at old age protects against cognitive impairment (CI) and Alzheimer's disease (AD), we prospectively studied 100 optimally healthy oldest-old (85 years) individuals. Initially, subjects represented the top 3% of the oldest old for health. During 5.6 ± 0.3 years of follow-up, 34 subjects developed CI, and 23 progressed to AD. By age 100, probability of CI and AD were .65 ± .09 and .49 ± .10. Median onset age was 97 years for CI and 100 for AD. Clearly, superior health at old age does not guarantee protection against cognitive decline. Lifetime risks were similar to the general population but onset ages were later, suggesting factors that delay onset are key to improving cognitive health in the elderly. In this population, absence of apolipoprotein E-ε4 and male gender were associated with delayed onset, whereas estrogen use and education had no detectable effect on cognitive outcome.
UR - http://www.scopus.com/inward/record.url?scp=0034953543&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034953543&partnerID=8YFLogxK
U2 - 10.1093/gerona/56.7.b294
DO - 10.1093/gerona/56.7.b294
M3 - Article
C2 - 11445594
AN - SCOPUS:0034953543
SN - 1079-5006
VL - 56
SP - B294-B301
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 7
ER -