TY - JOUR
T1 - Predictors of malignancy development in patients with chronic pruritus
AU - Fett, Nicole
AU - Haynes, Kevin
AU - Propert, Kathleen Joy
AU - Margolis, David J.
N1 - Funding Information:
The project described was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health , through Grant UL1TR000003 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2016 Elsevier Ireland Ltd.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Background: Patients with pruritus have been shown to have an increased incidence of certain subtypes of malignancy. Objective: To assess predictors of malignancy in patients with chronic pruritus without prior dermatologic diagnoses. Methods: Case-control study of 398 patients with chronic pruritus who developed a malignancy were compared with 8346 patients with chronic pruritus who did not develop a malignancy. Primary outcomes were odds of developing incident malignancy. Results: Age greater than 60 years (OR 4.04, 95% CI 3.08, 5.31), male sex (OR 1.39, 95% CI 1.13, 1.71) and liver disease (OR 2.37, 95% CI 1.00, 5.65) were predictors of malignancy development in patients with chronic pruritus and non-diseased skin. In an exploratory analysis with multiple imputation via chained equations, age greater than 60 years (OR 4.13, 95% CI 3.15, 5.42), male sex (OR 1.26, 95% CI 1.02, 1.55), and current or prior smoking (OR 2.02, 95% CI 1.42, 2.88) were predictors of malignancy development in patients with chronic pruritus and non-diseased skin. Limitations: Potential for misclassification and detection biases. Missing data. Conclusions and relevance: In patients with chronic pruritus without concomitant dermatologic diagnoses, older age, male sex, liver disease and tobacco abuse increase the odds of an underlying malignancy.
AB - Background: Patients with pruritus have been shown to have an increased incidence of certain subtypes of malignancy. Objective: To assess predictors of malignancy in patients with chronic pruritus without prior dermatologic diagnoses. Methods: Case-control study of 398 patients with chronic pruritus who developed a malignancy were compared with 8346 patients with chronic pruritus who did not develop a malignancy. Primary outcomes were odds of developing incident malignancy. Results: Age greater than 60 years (OR 4.04, 95% CI 3.08, 5.31), male sex (OR 1.39, 95% CI 1.13, 1.71) and liver disease (OR 2.37, 95% CI 1.00, 5.65) were predictors of malignancy development in patients with chronic pruritus and non-diseased skin. In an exploratory analysis with multiple imputation via chained equations, age greater than 60 years (OR 4.13, 95% CI 3.15, 5.42), male sex (OR 1.26, 95% CI 1.02, 1.55), and current or prior smoking (OR 2.02, 95% CI 1.42, 2.88) were predictors of malignancy development in patients with chronic pruritus and non-diseased skin. Limitations: Potential for misclassification and detection biases. Missing data. Conclusions and relevance: In patients with chronic pruritus without concomitant dermatologic diagnoses, older age, male sex, liver disease and tobacco abuse increase the odds of an underlying malignancy.
KW - Itch
KW - Malignancy risk factors
KW - Medical dermatology
KW - Pruritus
KW - Pruritus as a sign of systemic disease
KW - Screening for malignancy
UR - http://www.scopus.com/inward/record.url?scp=84957900886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957900886&partnerID=8YFLogxK
U2 - 10.1016/j.jdermsci.2016.01.010
DO - 10.1016/j.jdermsci.2016.01.010
M3 - Article
C2 - 26874971
AN - SCOPUS:84957900886
SN - 0923-1811
VL - 82
SP - 123
EP - 128
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
IS - 2
ER -