Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment

Kenneth D. Youngren; Bita Moghaddam; Benjamin S. Bunney; Robert H. Roth

doi:10.1016/0304-3940(94)90704-8

Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment

Kenneth D. Youngren, Bita Moghaddam, Benjamin S. Bunney, Robert H. Roth

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Abstract

The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day × 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.

Original language	English (US)
Pages (from-to)	41-44
Number of pages	4
Journal	Neuroscience Letters
Volume	165
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(94)90704-8
State	Published - Jan 3 1994
Externally published	Yes

Keywords

Clozapine
Dopamine
Microdialysis
Nucleus accumbens
Prefrontal cortex
Striatum

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(94)90704-8

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title = "Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment",

abstract = "The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day × 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.",

keywords = "Clozapine, Dopamine, Microdialysis, Nucleus accumbens, Prefrontal cortex, Striatum",

author = "Youngren, {Kenneth D.} and Bita Moghaddam and Bunney, {Benjamin S.} and Roth, {Robert H.}",

note = "Funding Information: The authors thank C.L. Pun for excellent technical assistance and Sandoz Pharmaceuticals for the generous gift of clozapine. This work was supported in part by USPHS Awards MH-14092, MH-28849 and MH-44866 and by Yale School of Medicine Dean's Young Faculty Award (to B. Moghaddam).",

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doi = "10.1016/0304-3940(94)90704-8",

language = "English (US)",

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AU - Youngren, Kenneth D.

AU - Moghaddam, Bita

AU - Bunney, Benjamin S.

AU - Roth, Robert H.

N1 - Funding Information: The authors thank C.L. Pun for excellent technical assistance and Sandoz Pharmaceuticals for the generous gift of clozapine. This work was supported in part by USPHS Awards MH-14092, MH-28849 and MH-44866 and by Yale School of Medicine Dean's Young Faculty Award (to B. Moghaddam).

PY - 1994/1/3

Y1 - 1994/1/3

N2 - The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day × 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.

AB - The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day × 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.

KW - Clozapine

KW - Dopamine

KW - Microdialysis

KW - Nucleus accumbens

KW - Prefrontal cortex

KW - Striatum

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ER -

Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment

Abstract

Keywords

ASJC Scopus subject areas

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