TY - JOUR
T1 - Preliminary evidence of a blunted anti-inflammatory response to exhaustive exercise in fibromyalgia
AU - Torgrimson-Ojerio, Britta
AU - Ross, Rebecca L.
AU - Dieckmann, Nathan F.
AU - Avery, Stephanie
AU - Bennett, Robert M.
AU - Jones, Kim D.
AU - Guarino, Anthony J.
AU - Wood, Lisa J.
N1 - Funding Information:
Funding for this study was provided by NIAMS R21AR056751 to LJW and KDJ. This publication was supported by the Oregon Clinical and Translational Research Institute (OCTRI) , grant number ( UL1TR000128 ) from the National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) ( R21AR056751 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2014 The Authors.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Exercise intolerance, as evidenced by a worsening of pain, fatigue, and stiffness after novel exertion, is a key feature of fibromyalgia (FM). In this pilot study, we investigate whether; insufficient muscle repair processes and impaired anti-inflammatory mechanisms result in an exaggerated pro-inflammatory cytokine response to exhaustive exercise, and consequently a worsening of muscle pain, stiffness and fatigue in the days post-exercise. We measured changes in muscle pain and tenderness, fatigue, stiffness, and serum levels of neuroendocrine and inflammatory cytokine markers in 20 women with FM and 16 healthy controls (HCs) before and after exhaustive treadmill exercise. Compared to HCs, FM participants failed to mount the expected anti-inflammatory response to exercise and experienced a worsening of symptoms post-exercise. However, changes in post-exertional symptoms were not mediated by post-exertional changes in pro-inflammatory cytokine levels. Implications of these findings are discussed.
AB - Exercise intolerance, as evidenced by a worsening of pain, fatigue, and stiffness after novel exertion, is a key feature of fibromyalgia (FM). In this pilot study, we investigate whether; insufficient muscle repair processes and impaired anti-inflammatory mechanisms result in an exaggerated pro-inflammatory cytokine response to exhaustive exercise, and consequently a worsening of muscle pain, stiffness and fatigue in the days post-exercise. We measured changes in muscle pain and tenderness, fatigue, stiffness, and serum levels of neuroendocrine and inflammatory cytokine markers in 20 women with FM and 16 healthy controls (HCs) before and after exhaustive treadmill exercise. Compared to HCs, FM participants failed to mount the expected anti-inflammatory response to exercise and experienced a worsening of symptoms post-exercise. However, changes in post-exertional symptoms were not mediated by post-exertional changes in pro-inflammatory cytokine levels. Implications of these findings are discussed.
KW - Cortisol
KW - Cytokine
KW - Exercise
KW - Fatigue
KW - Fibromyalgia
KW - Stiffness
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U2 - 10.1016/j.jneuroim.2014.10.003
DO - 10.1016/j.jneuroim.2014.10.003
M3 - Article
C2 - 25457842
AN - SCOPUS:84918802036
SN - 0165-5728
VL - 277
SP - 160
EP - 167
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -