Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin

Alfred J. Lewy; Brant P. Hasler; Jonathan S. Emens; Robert L. Sack

doi:10.1016/S0304-3940(01)02261-3

Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin

Alfred J. Lewy, Brant P. Hasler, Jonathan S. Emens, Robert L. Sack

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

To date, we have entrained (synchronized) eight totally blind people with free-running circadian rhythms to a nightly dose of 10 mg of melatonin. Each person entrained at a different phase angle of entrainment (PAE), which is the interval in hours between the time of the melatonin dose and the time of the endogenous melatonin onset. When the PAE was plotted against the pretreatment free-running (i.e. slightly different than 24.0 h) circadian period (tau), the fitted regression line revealed a significant correlation, which is consistent with previous findings on light entrainment of rest-activity rhythms in free-running rodents.

Original language	English (US)
Pages (from-to)	158-160
Number of pages	3
Journal	Neuroscience Letters
Volume	313
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(01)02261-3
State	Published - Nov 9 2001

Keywords

Circadian period
Circadian phase
Melatonin
Melatonin amplitude
Melatonin assays
Melatonin onset (MO)
Phase angle of entrainment (PAE)
Tau

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0304-3940(01)02261-3

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title = "Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin",

abstract = "To date, we have entrained (synchronized) eight totally blind people with free-running circadian rhythms to a nightly dose of 10 mg of melatonin. Each person entrained at a different phase angle of entrainment (PAE), which is the interval in hours between the time of the melatonin dose and the time of the endogenous melatonin onset. When the PAE was plotted against the pretreatment free-running (i.e. slightly different than 24.0 h) circadian period (tau), the fitted regression line revealed a significant correlation, which is consistent with previous findings on light entrainment of rest-activity rhythms in free-running rodents.",

keywords = "Circadian period, Circadian phase, Melatonin, Melatonin amplitude, Melatonin assays, Melatonin onset (MO), Phase angle of entrainment (PAE), Tau",

author = "Lewy, {Alfred J.} and Hasler, {Brant P.} and Emens, {Jonathan S.} and Sack, {Robert L.}",

note = "Funding Information: We thank the nursing staff of the Oregon Health & Science University (OHSU) General Clinical Research Center (GCRC); Richard Brandes, Hillary Bish, Anju Bhargava, Rebecca Bernert, Neil Anderson and Rick Boney for technical assistance; Gary Sexton Ph.D. for statistical advice; and Keith Parrott, Pharm. D. for the formulation of melatonin capsules. This work was supported by Public Health Service Research Grants R01 MH56874 (RLS), R01 MH55703 (AjL) R01 AG15140 (Ajl) and RR00334 (OHSU GCRC). ",

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AU - Lewy, Alfred J.

AU - Hasler, Brant P.

AU - Emens, Jonathan S.

AU - Sack, Robert L.

N1 - Funding Information: We thank the nursing staff of the Oregon Health & Science University (OHSU) General Clinical Research Center (GCRC); Richard Brandes, Hillary Bish, Anju Bhargava, Rebecca Bernert, Neil Anderson and Rick Boney for technical assistance; Gary Sexton Ph.D. for statistical advice; and Keith Parrott, Pharm. D. for the formulation of melatonin capsules. This work was supported by Public Health Service Research Grants R01 MH56874 (RLS), R01 MH55703 (AjL) R01 AG15140 (Ajl) and RR00334 (OHSU GCRC).

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N2 - To date, we have entrained (synchronized) eight totally blind people with free-running circadian rhythms to a nightly dose of 10 mg of melatonin. Each person entrained at a different phase angle of entrainment (PAE), which is the interval in hours between the time of the melatonin dose and the time of the endogenous melatonin onset. When the PAE was plotted against the pretreatment free-running (i.e. slightly different than 24.0 h) circadian period (tau), the fitted regression line revealed a significant correlation, which is consistent with previous findings on light entrainment of rest-activity rhythms in free-running rodents.

AB - To date, we have entrained (synchronized) eight totally blind people with free-running circadian rhythms to a nightly dose of 10 mg of melatonin. Each person entrained at a different phase angle of entrainment (PAE), which is the interval in hours between the time of the melatonin dose and the time of the endogenous melatonin onset. When the PAE was plotted against the pretreatment free-running (i.e. slightly different than 24.0 h) circadian period (tau), the fitted regression line revealed a significant correlation, which is consistent with previous findings on light entrainment of rest-activity rhythms in free-running rodents.

KW - Circadian period

KW - Circadian phase

KW - Melatonin

KW - Melatonin amplitude

KW - Melatonin assays

KW - Melatonin onset (MO)

KW - Phase angle of entrainment (PAE)

KW - Tau

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Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin

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Keywords

ASJC Scopus subject areas

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