TY - JOUR
T1 - Prevalence of left heart contrast in healthy, young, asymptomatic humans at rest breathing room air
AU - Elliott, Jonathan E.
AU - Nigam, S. Milind
AU - Laurie, Steven S.
AU - Beasley, Kara M.
AU - Goodman, Randall D.
AU - Hawn, Jerold A.
AU - Gladstone, Igor M.
AU - Chesnutt, Mark S.
AU - Lovering, Andrew T.
N1 - Funding Information:
We thank Mr. Collin P. Bailey, BS, Ms. Caitlyn E. Gust, BS, Ms. Julia P. Kern, BS, Ms. Heidi A. Straub, BS, Mr. Matthew J. Hadeed, BS, and Tyler S. Mangum, BS, for technical assistance. This work was completed in partial fulfillment of the honors thesis for Mr. S. Milind Nigam, BS, in the Robert D. Clark Honors College at the University of Oregon. This work was supported by Oregon Health & Science University Medical Research Foundation Grant ( #0820 ), American Heart Association Scientist Development Grant ( #2280238 ), American Physiological Society's Giles F. Filley Memorial Award for Excellence in Respiratory Physiology & Medicine, American Heart Association Predoctoral Fellowship, and Defense Medical Research and Development Program ( #W81XWH-10-2-0114/#DM1027581 JTCG5 TATRC ).
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Our purpose was to report the prevalence of healthy, young, asymptomatic humans who demonstrate left heart contrast at rest, breathing room air. We evaluated 176 subjects (18-41 years old) using transthoracic saline contrast echocardiography. Left heart contrast appearing ≤3 cardiac cycles, consistent with a patent foramen ovale (PFO), was detected in 67 (38%) subjects. Left heart contrast appearing >3 cardiac cycles, consistent with the transpulmonary passage of contrast, was detected in 49 (28%) subjects. Of these 49 subjects, 31 were re-evaluated after breathing 100% O2 for 10-15min and 6 (19%) continued to demonstrate the transpulmonary passage of contrast. Additionally, 18 of these 49 subjects were re-evaluated in the upright position and 1 (5%) continued to demonstrate the transpulmonary passage of contrast. These data suggest that ~30% of healthy, young, asymptomatic subjects demonstrate the transpulmonary passage of contrast at rest which is reduced by breathing 100% O2 and assuming an upright body position.
AB - Our purpose was to report the prevalence of healthy, young, asymptomatic humans who demonstrate left heart contrast at rest, breathing room air. We evaluated 176 subjects (18-41 years old) using transthoracic saline contrast echocardiography. Left heart contrast appearing ≤3 cardiac cycles, consistent with a patent foramen ovale (PFO), was detected in 67 (38%) subjects. Left heart contrast appearing >3 cardiac cycles, consistent with the transpulmonary passage of contrast, was detected in 49 (28%) subjects. Of these 49 subjects, 31 were re-evaluated after breathing 100% O2 for 10-15min and 6 (19%) continued to demonstrate the transpulmonary passage of contrast. Additionally, 18 of these 49 subjects were re-evaluated in the upright position and 1 (5%) continued to demonstrate the transpulmonary passage of contrast. These data suggest that ~30% of healthy, young, asymptomatic subjects demonstrate the transpulmonary passage of contrast at rest which is reduced by breathing 100% O2 and assuming an upright body position.
KW - Intrapulmonary arteriovenous anastomoses
KW - Patent foramen ovale
KW - Right-to-left shunt
KW - Transthoracic saline contrast echocardiography
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U2 - 10.1016/j.resp.2013.04.019
DO - 10.1016/j.resp.2013.04.019
M3 - Article
C2 - 23648476
AN - SCOPUS:84879363790
SN - 1569-9048
VL - 188
SP - 71
EP - 78
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 1
ER -