Primary cortisol resistance: A family study

George P. Chrousos, Adrian C.M. Vingerhoeds, D. Lynn Loriaux, Mortimer B. Lipsett

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Primary cortisol resistance is an autosomal disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of clinical stigmata of Cushing’s syndrome. The proband with the severe form had hypertension and hypokalemic alkalosis. In subjects with a less severe resistance to cortisol, there are no clinical abnormalities and the condition is revealed only by detailed examination of several parameters of cortisol secretion.

Original languageEnglish (US)
Pages (from-to)1243-1245
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
StatePublished - Jun 1983
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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