TY - JOUR
T1 - Primary gliosarcoma
T2 - Key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity
AU - Han, Seunggu J.
AU - Yang, Isaac
AU - Tihan, Tarik
AU - Prados, Michael D.
AU - Parsa, Andrew T.
PY - 2010/2
Y1 - 2010/2
N2 - This report presents the historical experience, clinical presentation, treatment, prognosis, and pathogenesis of gliosarcoma described to date in the English literature. PubMed query of term "gliosarcoma" was performed, followed by a rigorous review of cited literature. Articles selected for analysis included: (1) case reports of gliosarcoma, (2) review articles of gliosarcoma, and (3) studies of the pathogenesis or genetics of gliosarcoma in humans. Our review identified 219 cases of gliosarcoma in 34 reports and eight articles addressing the pathogenesis. Survival in larger series ranged 4-11.5 months. Features unique to gliosarcoma compared to glioblastoma (GBM) include their temporal lobe predilection, potential to appear similar to a meningioma at surgery, repeated reports of extracranial metastases, and infrequency of EGFR mutations. Published experience is limited to small case series, and the pathogenesis remains unclear. Clinical and pathologic characteristics distinct from GBM suggest that they may warrant specific treatment, separate from conventional GBM therapy.
AB - This report presents the historical experience, clinical presentation, treatment, prognosis, and pathogenesis of gliosarcoma described to date in the English literature. PubMed query of term "gliosarcoma" was performed, followed by a rigorous review of cited literature. Articles selected for analysis included: (1) case reports of gliosarcoma, (2) review articles of gliosarcoma, and (3) studies of the pathogenesis or genetics of gliosarcoma in humans. Our review identified 219 cases of gliosarcoma in 34 reports and eight articles addressing the pathogenesis. Survival in larger series ranged 4-11.5 months. Features unique to gliosarcoma compared to glioblastoma (GBM) include their temporal lobe predilection, potential to appear similar to a meningioma at surgery, repeated reports of extracranial metastases, and infrequency of EGFR mutations. Published experience is limited to small case series, and the pathogenesis remains unclear. Clinical and pathologic characteristics distinct from GBM suggest that they may warrant specific treatment, separate from conventional GBM therapy.
KW - Gliosarcoma
KW - Primary gliosarcoma
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=75049083515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75049083515&partnerID=8YFLogxK
U2 - 10.1007/s11060-009-9973-6
DO - 10.1007/s11060-009-9973-6
M3 - Review article
C2 - 19618114
AN - SCOPUS:75049083515
SN - 0167-594X
VL - 96
SP - 313
EP - 320
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
IS - 3
ER -